Publications

Sleep and rest-activity-rhythm abnormalities are commonly reported in schizophrenia spectrum disorder patients. However, an in-depth characterization of sleep and rest-activity-rhythm alterations in schizophrenia spectrum disorder, including patients in different treatment settings, and the relationship between these alterations and schizophrenia spectrum disorder clinical features, is lacking. Characterization of...

Major depressive disorder (MDD) is associated with substantial psychosocial impairment, increased risk for suicide, and morbidity. As a first-line treatment for MDD, many patients receive cognitive behavioral therapy (CBT) or interpersonal psychotherapy (IPT), interventions that have been typically delivered face-to-face. Despite the ubiquity of telehealth following the COVID-19 pandemic, little is known about...

Complex and coordinated brain development progresses rapidly within the first year of a baby’s life, and infant white matter development is associated with future cognitive processes and behavioral problems. Elucidating the neural basis of infant emotional behaviors can identify biomarkers of pathophysiological risk for subsequent behavioral and emotional problems. In Biological Psychiatry, investigators including...

Newborns with prenatal opioid exposure present with symptoms and dysregulated behaviors of the central and autonomic nervous systems that are commonly attributed to neonatal opioid withdrawal syndrome. Pharmacologic agents (e.g., morphine, methadone) are often used to treat newborns with prenatal opioid exposure, despite known adverse effects on neurodevelopment. To reduce the consequences of in utero opioid...

In the first years of life, affective state matching, in which mothers and children imitate and elaborate on each other’s positive emotional expressions—through shared smiling, mutual eye gaze, back-and-forth vocalizations, and joint play—is a hallmark of early mother-child interactions. In addition, positive affective state matching also appears to promote child emotional self-regulation through the process in...

Two recent studies from Pitt Psychiatry have examined neurocognitive and cardiometabolic function in retired night shift workers compared with retired day shift workers. The late Tica Hall, PhD, an internationally recognized expert in sleep and circadian science, served as senior author of both studies, and we recognize this important work in honor of her memory. Cardiometabolic function in retired night shift...