Publications

Anxiety disorders are prevalent in late life, with symptoms including severe (uncontrollable) worry and rumination. Late-life anxiety, worry, and rumination in the context of the aging brain can be associated with differences in volume and thickness of gray matter regions in the brain, as well as altered functional connectivity in the networks involved in emotion generation and regulation, but these changes may...

Up to 50% of youth with bipolar spectrum disorder attempt suicide, and of all psychiatric diagnoses, bipolar spectrum disorder imparts the greatest risk of death by suicide in adolescents. Although multiple psychosocial interventions are effective for mood stabilization and for decreasing the risk of mood episode recurrence, no treatment specifically targets suicidal behavior in youth with bipolar spectrum disorder...

Recent studies led by Pitt Psychiatry investigators examine the associations between post-traumatic stress disorder and cardiovascular and brain health in women ( JAMA Network Open), and sex-dependent alterations in the memory network ( Alzheimer’s & Dementia). Posttraumatic Stress Disorder Symptoms and Cardiovascular and Brain Health in Women Most women in the United States will experience at least one major...

Bipolar disorder, which has peak onset in early adulthood, is often difficult to accurately diagnose due to misreporting mania/hypomania, even though mania/hypomania is a pathognomonic feature of the disorder. The misreporting of this feature frequently results in mistaking bipolar disorder for unipolar depression. To facilitate earlier and accurate bipolar disorder diagnoses, there is a vital need for objective...

Individuals with schizophrenia exhibit pronounced deficits in somatostatin messenger RNA levels in the dorsolateral prefrontal cortex and other prefrontal regions. Lower somatostatin messenger RNA levels appear to be due to lower gene expression per neuron without a deficit in somatostatin-positive neuron density, suggesting that in schizophrenia, somatostatin neurons are functionally altered in the dorsolateral...

Theories of human neurobehavioral development suggest executive functions mature from childhood through adolescence, a time when individuals may also experience peaks in risk-taking behaviors such as substance use, and increased vulnerability to psychiatric disorders. However, the timing of adolescent executive function development and the specific age when executive functions reach adult levels have been...