Publications

In schizophrenia, impaired working memory is associated with transcriptome alterations in layer 3 pyramidal neurons in the dorsolateral prefrontal cortex. Distinct subtypes of layer 3 pyramidal neurons that send axonal projections to the dorsolateral prefrontal cortex in the opposite hemisphere (callosal projection neurons) or the parietal cortex in the same hemisphere (ipsilateral projection neurons) play critical...

In both children and animal models, adverse childhood experiences lead to cognitive and behavioral impairments that have profound influence on behavior and health throughout the lifespan. To improve our understanding of the long-lasting impact of early stress exposure, the specific brain circuits impacted by early stress, and the mechanisms underlying each aspect of the influence of stress exposure, investigators...

Over the past decade, rates of suicidal ideation and behavior in American adolescents have increased dramatically. One strategy for preventing suicide is to develop interventions for use during elevated risk periods, such as immediately following inpatient discharge for suicidal adolescents. The time during and immediately after hospital discharge offers a critical window to enhance vulnerable youths’ coping skills...

Poor sleep is prevalent in adolescents with bipolar disorder, precedes illness onset, and is associated with worse mood symptoms. Furthermore, adolescents with bipolar disorder are at a heightened risk for suicidal behavior. Because many risk factors for suicidal behavior (e.g., prior history of trauma, family history of bipolar disorder) are not modifiable, it is critical to identify novel risk factors for bipolar...

People who survive suicide attempts usually come to regret their choice of suicide attempt over constructive alternatives, suggesting that this choice is often an error of decision-making. In a crisis, decisions are often made during a complex sensorimotor interaction, with real or perceived time pressure, and a vast number of options that may become available and vanish dynamically. While there may be many choices...

Most studies examining dopaminergic modulation of metabolism have focused on D 2-like receptors (D 2, D 3, and D 4 receptors) in brain regions associated with metabolic regulation, including striatum and hypothalamus, where D 2 and D 3 receptors mediate appetite, feeding, and central glucose sensing. However, dopamine D 2-like receptors in both the central nervous system and the periphery are key modulators of...