Publications

Poor sleep is prevalent in adolescents with bipolar disorder, precedes illness onset, and is associated with worse mood symptoms. Furthermore, adolescents with bipolar disorder are at a heightened risk for suicidal behavior. Because many risk factors for suicidal behavior (e.g., prior history of trauma, family history of bipolar disorder) are not modifiable, it is critical to identify novel risk factors for bipolar...

People who survive suicide attempts usually come to regret their choice of suicide attempt over constructive alternatives, suggesting that this choice is often an error of decision-making. In a crisis, decisions are often made during a complex sensorimotor interaction, with real or perceived time pressure, and a vast number of options that may become available and vanish dynamically. While there may be many choices...

Most studies examining dopaminergic modulation of metabolism have focused on D 2-like receptors (D 2, D 3, and D 4 receptors) in brain regions associated with metabolic regulation, including striatum and hypothalamus, where D 2 and D 3 receptors mediate appetite, feeding, and central glucose sensing. However, dopamine D 2-like receptors in both the central nervous system and the periphery are key modulators of...

The most effective treatments for depression include pharmacotherapy and psychotherapy, but a pressing need remains for rapid, efficacious treatments. While the administration of ketamine can reduce depressive symptoms within two to 24 hours, these effects dissipate in a brief period following a single infusion. Rebecca Price, PhD (Associate Professor of Psychiatry and Psychology), and colleagues wanted to see...

Although reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume, a key indicator of cerebral small vessel disease linked to future risk for stroke, dementia, and mortality. Studies of hormones and the brain in women typically focus on estradiol, the main ovarian estrogen. However, hallmark changes of...