Publications

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Biological Psychiatry – The Impact of Intravenous Ketamine on Attentional Bias: Probing Mechanisms of Rapid-Acting Antidepressant Effects in Two Clinical Studies

Biological Psychiatry

Intravenous ketamine produces reliable, fast-acting, and potent antidepressant effects even among individuals with treatment-resistant depression. Ketamine can also be a powerful experimental tool to provide a more precise evaluation of neurocognitive mechanisms underlying reduction in depression symptoms. Cognitive theorists of depression have long posited that systematic alterations in attentional bias (giving...

Neuropsychopharmacology: Brain and Cardiovascular Responses to Acute Stress in Remitted and Recurrent Late-Life Depression

Neuropsychopharmacology

Among older adults who successfully achieve clinical remission from depression, 35%-45% will experience a new depressive episode within two years. The factors that contribute to the emergence of recurrent depressive episodes in older adults are not well understood. Psychological stress may play a role in depression remission and recurrence, yet important questions remain about the brain and physiological profiles...

Neurobiology of Disease: Phosphorylated-tau Associates with HSV-1 Chromatin and Correlates with Nuclear Speckles Decondensation in Low-Density Host Chromatin Regions

Leonardo D'Aiuto, PhD

Abnormal tau phosphorylation is a key pathophysiological mechanism in neurodegenerative diseases. In addition to genetic and environmental factors, infectious agents, such as Herpes Simplex Virus 1, may be associated with the onset or progression of neurodegenerative diseases, including Alzheimer's disease. However, outstanding questions remain regarding the contribution of viruses in the etiology of...

Journal of Research in Personality: Facets of Trait Impulsivity and Their Relationships to Developmental Trajectories of Externalizing Behaviors from Childhood into Early Adolescence

Dr. Frances Wang

Adolescence is a vulnerable period for externalizing behaviors (e.g., disruptive, rule-breaking behaviors including aggression, delinquency, or substance use) as the ability to self-regulate behaviors and emotions is still maturing. Impulsivity is a risk factor for externalizing behaviors, although the unique relationships between specific impulsivity facets and externalizing behavior development are unclear...

Journal of Adolescent Health: The Impact of Insufficient Sleep on White Matter Development in Late Childhood and Early Adolescence

Journal of Adolescent Health

Early adolescence is associated with major changes in sleep-circadian processes, which, combined with biopsychosocial factors, contribute to a decline in sleep duration. Insufficient sleep in childhood and adolescence is associated with future adverse cognitive and mental health outcomes including depression and anxiety. As part of a Brain & Behavior Research Foundation Young Investigator Grant, scientists from...

Pitt Psychiatry Research Published in Molecular Psychiatry

Collage of Molecular Psychiatry Co-Authors

Multiple Pitt Psychiatry investigators have recently published studies in Molecular Psychiatry. Below is a roundup of recent original research on adolescent neurodevelopment, aging and cognition, and the association between sleep and psychosis. Adolescent maturation of dorsolateral prefrontal cortex glutamate: GABA and cognitive function is supported by dopamine-related neurobiology Pitt Psychiatry investigators...

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