Publications

Authored on

Recently Published in Autism Research & Psychological Medicine: Advances in Understanding of Self-Injury and Adult Outcome Measurement to Improve Quality of Life

Drs. Antezana, Conner and Mazefsky

Recent studies led by Carla Mazefsky, PhD (Nancy J. Minshew, MD Chair in Autism Research and Professor of Psychiatry, Clinical and Translational Science, and Psychology), highlight current advances in autism research. Dr. Mazefsky is an expert in emotion regulation in autism, which had been previously understudied in autism research. She directs the Regulation of Emotion in Autistic Adults, Children, and Teens...

Journal of the American Geriatrics Society: Social Determinants of Health and Mild Cognitive Impairment in a Representative Community Sample

Study Map Showing Sample from Allegheny County

Social determinants of health are non-medical factors of daily life that influence health outcomes. A review of factors influencing cognitive impairment in older adults presented a range of community-level structural and social determinants of health, distinguished from individual risk and protective factors. Investigators led by Mary Ganguli, MD, MPH (Professor of Psychiatry, Epidemiology, and Neurology), analyzed...

Biological Psychiatry – The Impact of Intravenous Ketamine on Attentional Bias: Probing Mechanisms of Rapid-Acting Antidepressant Effects in Two Clinical Studies

Biological Psychiatry

Intravenous ketamine produces reliable, fast-acting, and potent antidepressant effects even among individuals with treatment-resistant depression. Ketamine can also be a powerful experimental tool to provide a more precise evaluation of neurocognitive mechanisms underlying reduction in depression symptoms. Cognitive theorists of depression have long posited that systematic alterations in attentional bias (giving...

Neuropsychopharmacology: Brain and Cardiovascular Responses to Acute Stress in Remitted and Recurrent Late-Life Depression

Neuropsychopharmacology

Among older adults who successfully achieve clinical remission from depression, 35%-45% will experience a new depressive episode within two years. The factors that contribute to the emergence of recurrent depressive episodes in older adults are not well understood. Psychological stress may play a role in depression remission and recurrence, yet important questions remain about the brain and physiological profiles...

Neurobiology of Disease: Phosphorylated-tau Associates with HSV-1 Chromatin and Correlates with Nuclear Speckles Decondensation in Low-Density Host Chromatin Regions

Leonardo D'Aiuto, PhD

Abnormal tau phosphorylation is a key pathophysiological mechanism in neurodegenerative diseases. In addition to genetic and environmental factors, infectious agents, such as Herpes Simplex Virus 1, may be associated with the onset or progression of neurodegenerative diseases, including Alzheimer's disease. However, outstanding questions remain regarding the contribution of viruses in the etiology of...

Journal of Research in Personality: Facets of Trait Impulsivity and Their Relationships to Developmental Trajectories of Externalizing Behaviors from Childhood into Early Adolescence

Dr. Frances Wang

Adolescence is a vulnerable period for externalizing behaviors (e.g., disruptive, rule-breaking behaviors including aggression, delinquency, or substance use) as the ability to self-regulate behaviors and emotions is still maturing. Impulsivity is a risk factor for externalizing behaviors, although the unique relationships between specific impulsivity facets and externalizing behavior development are unclear...

Browse by year