Publications

Identifying the neural markers of pathophysiological processes underlying depression severity can provide targets to guide treatment choice for individuals with subsyndromal or syndromal-level depression. This approach is particularly important for young adults with depression due to the high incidence of affective disorders during this age range, and because the effectiveness of interventions can be maximized...

A group of Alzheimer’s and dementia investigators have published a study in Brain reporting the development and the analytical and clinical validation of a novel biomarker for Alzheimer’s disease. Led by Thomas Karikari, PhD (Assistant Professor of Psychiatry)—and including senior scientists Henrik Zetterberg, MD, PhD, and Kaj Blennow, MD, PhD, internationally renowned leaders in blood biomarker discovery at...

Postmortem studies of the prefrontal cortex have revealed changes in gamma-aminobutyric acid and glutamate across adolescence, which suggests shifts in excitation and inhibition balance consistent with critical period plasticity. However, questions have persisted regarding how gamma-aminobutyric acid and glutamate change through adolescence and how the balance of these inhibitory and excitatory neurotransmitters...

Models of the aging process are becoming prevalent in multiple fields, and over the last decade, scientists have used brain aging markers to identify important neuroanatomical differences in multiple psychiatric disorders. These markers may provide individualized risk assessments and predictions for age-associated neurodegenerative diseases, and have recently been used to demonstrate the association between greater...

Psychosis, an impairment that manifests as hallucinations and/or delusions, is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Individuals suffering with these illnesses also have major disruptions in sleep and circadian rhythms, which can precipitate or exacerbate psychotic symptoms. A group of investigators including Kyle Ketchesin, PhD (Assistant Professor of Psychiatry), Madeline...

Major depressive disorder is among the most prevalent psychiatric disorders, affecting nearly 300 million people worldwide, and exacting a substantial personal, social, and economic toll. Antidepressant treatment typically involves an individualized trial-and-error approach with an inconsistent success rate. Given the negative outcomes associated with depression, there is a pressing need for the development of...