Publications

Alcohol use is responsible for about 4% of all deaths worldwide. Alcohol abuse and dependence are also frequently seen in individuals diagnosed with head and neck cancer. Defining the factors that contribute to this increased risk for these cancers is critical to the ultimate goal of reducing cancer development. Because about 30% of all types of cancers involve the HRAS oncogene, its expression is of importance to...

Published in Translational Psychiatry Severe worry arises from a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field regarding the neural basis of worry. No previous study has looked at cerebral blood flow changes associated specifically with in-scanner induction and reappraisal of worry. In the first study of its kind, Department of...

Published in Molecular Psychiatry Department of Psychiatry members John Enwright, PhD; Dominique Arion, PhD; and David A. Lewis, MD, along with colleagues from other departments, have identified cell type-specific molecular alterations in schizophrenia, which could propel strategies for identifying novel therapeutic targets. The researchers investigated the molecular alterations associated with schizophrenia at the...

Early identification of individuals at high risk for the onset of bipolar spectrum disorder (BPSD) is key from both a clinical and research perspective. In this study, Dr. Hafeman and colleagues built a risk calculator to predict the five-year onset of BPSD in youth at familial risk. This study tested the degree to which a time-to-event model, including measures of mood and anxiety, general psychosocial functioning...