Publications

Childhood and adult trauma both correlate with dorsal anterior cingulate activation to threat in combat veteransHerringa RJ, Phillips ML, Fournier JC, Kronhaus DM, Germain A Childhood maltreatment is a major risk factor for the development of posttraumatic stress symptoms (PTSS) following trauma in adulthood. Yet, the brain mechanisms underlying this vulnerability remain poorly understood. This study, led by Dr...

Differential patterns of activity and functional connectivity in emotion processing neural circuitry to angry and happy faces in adolescents with and without suicide attempt. Pan LA, Hassel S, Segreti AM, Nau SA, Brent DA, Phillips ML. Suicidal behavior is a leading cause of morbidity and mortality in adolescence. Despite progress in understanding risk factors for suicidal behavior, the pathogenesis is poorly...

Imaging dopamine transmission in the frontal cortex: a simultaneous microdialysis and [(11)C]FLB 457 PET study Narendran R, Jedema HP, Lopresti BJ, Mason NS, Gurnsey K, Ruszkiewicz J, Chen CM, Deuitch L, Frankle WG, Bradberry CW. Abnormal dopamine levels in the brain?s prefrontal cortex have a negative effect on neurocognitive functions, such as memory, attention and problem-solving. Altered levels of the...

Adolescent Initiation of Drug Use: Effects of Prenatal Cocaine Exposure,Richardson, GA, Larkby, C, Goldschmidt, L, Day, NL Very few studies have focused on the effects that drug exposure during pregnancy may have on subsequent drug use in the offspring. In a study published in the Journal of the American Academy of Child & Adolescent Psychiatry, Dr. Richardson and colleagues in the Department of Psychiatry...

JAMA Clinical Crossroads Features Sleep Researcher JAMA recently featured sleep researcher Daniel Buysse, MD as part of the journal's Clinical Crossroads section focusing on insomnia. The article is based on a Clinical Grand Rounds presented by Dr. Buysse at the Beth Israel Deaconess Medical Center in Boston. The case study involved a 51-year old woman whose insomnia was first diagnosed when she was age 35 and her...

An Important Role for Cholecystokinin, a CLOCK Target Gene, in the Development and Treatment of Manic-like Behaviors Arey RN, Enwright JF III, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA. Bipolar disorder, characterized by alternating periods of mania and depression, has been associated with disruptions in circadian rhythms, the biological processes that occur on a roughly 24-hour cycle...