Faculty

Kyle D Ketchesin, PhD

Kyle D Ketchesin, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Email

Education & Training

PhD
Neuroscience, University of Michigan
Psychiatry, University of Pittsburgh School of Medicine

Professional Affiliations

Member, Sleep Research Society
Member, Molecular Psychiatry Association
Member, Society for Research on Biological Rhythms

Research Interests

Circadian rhythms in mood disorders; Epigenetics; Multi-omics
Selected Research Publications & Products
  1. Logan RW, Xue X, Ketchesin KD, Hoffman G, Roussos P, Tseng G, McClung CA & Seney ML. (2022). Sex differences in molecular rhythms in the human cortex. Biological Psychiatry, 91(1):152-162.
  2. Ketchesin KD, Zong W, Hildebrand MA, Seney ML, Cahill KM, Scott MR, Shankar VG, Glausier JR, Lewis DA, Tseng GC & McClung CA. (2021). Diurnal rhythms across the human dorsal and ventral striatum. Proceedings of the National Academy of Sciences, 118(2):e2016150118.
  3. Logan RW, Ozburn AR, Arey RN, Ketchesin KD, Winquist A, Crain A, Tobe BTD, Becker-Krail D, Jarpe MB, Xue X, Zong W, Huo Z, Parekh PK, Zhu X, Fitzgerald E, Zhang H, Oliver-Smith J, DePoy LM, Hildebrand MA, Snyder EY, Tseng GC & McClung CA. (2021). Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2. Molecular Psychiatry, 26(8):4066-4084.
  4. Ketchesin KD, Becker-Krail D & McClung CA. (2020). Mood-related central and peripheral clocks. European Journal of Neuroscience, 51(1):326-345.
  5. Parekh PK, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MA, Hildebrand MA, Barko K, Huang YH & McClung CA. (2019). Cell-type-specific regulation of nucleus accumbens synaptic plasticity and cocaine reward sensitivity by the circadian protein, NPAS2. Journal of Neuroscience, 39(24):4657-4667.

Pitt Psychiatry News from the 2023 American College of Neuropsychopharmacology Annual Meeting

2023 ACNP Annual Meeting Collage

Many University of Pittsburgh Department of Psychiatry faculty and trainees attended the 2023 American College of Neuropsychopharmacology (ACNP) annual meeting to learn about and present new research, and connect with colleagues. Below is a recap of Pitt Psychiatry news from the meeting: Honorific Award Mary Phillips, MD, MD (Cantab) (Distinguished Professor of Psychiatry, Clinical and Translational Science, and...

Biological Psychiatry: Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis

Drs. Kyle Ketchesin & Colleen McClung

Psychosis, an impairment that manifests as hallucinations and/or delusions, is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Individuals suffering with these illnesses also have major disruptions in sleep and circadian rhythms, which can precipitate or exacerbate psychotic symptoms. A group of investigators including Kyle Ketchesin, PhD (Assistant Professor of Psychiatry), Madeline...

Biological Psychiatry: Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior

Dr. Colleen McClung

Individuals with substance use disorders have disrupted circadian and sleep/wake rhythms, and growing evidence suggests a bidirectional relationship between circadian rhythm disruption and substance abuse. Notably, circadian clocks are integral to the modulation of reward behaviors, and astrocytes—a highly abundant glial cell type that contains a circadian molecular clock—have emerged as key regulators of circadian...