Publications

Authored on

Neurobiology of Disease: Phosphorylated-tau Associates with HSV-1 Chromatin and Correlates with Nuclear Speckles Decondensation in Low-Density Host Chromatin Regions

Leonardo D'Aiuto, PhD

Abnormal tau phosphorylation is a key pathophysiological mechanism in neurodegenerative diseases. In addition to genetic and environmental factors, infectious agents, such as Herpes Simplex Virus 1, may be associated with the onset or progression of neurodegenerative diseases, including Alzheimer's disease. However, outstanding questions remain regarding the contribution of viruses in the etiology of...

Journal of Research in Personality: Facets of Trait Impulsivity and Their Relationships to Developmental Trajectories of Externalizing Behaviors from Childhood into Early Adolescence

Dr. Frances Wang

Adolescence is a vulnerable period for externalizing behaviors (e.g., disruptive, rule-breaking behaviors including aggression, delinquency, or substance use) as the ability to self-regulate behaviors and emotions is still maturing. Impulsivity is a risk factor for externalizing behaviors, although the unique relationships between specific impulsivity facets and externalizing behavior development are unclear...

Journal of Adolescent Health: The Impact of Insufficient Sleep on White Matter Development in Late Childhood and Early Adolescence

Journal of Adolescent Health

Early adolescence is associated with major changes in sleep-circadian processes, which, combined with biopsychosocial factors, contribute to a decline in sleep duration. Insufficient sleep in childhood and adolescence is associated with future adverse cognitive and mental health outcomes including depression and anxiety. As part of a Brain & Behavior Research Foundation Young Investigator Grant, scientists from...

Pitt Psychiatry Research Published in Molecular Psychiatry

Collage of Molecular Psychiatry Co-Authors

Multiple Pitt Psychiatry investigators have recently published studies in Molecular Psychiatry. Below is a roundup of recent original research on adolescent neurodevelopment, aging and cognition, and the association between sleep and psychosis. Adolescent maturation of dorsolateral prefrontal cortex glutamate: GABA and cognitive function is supported by dopamine-related neurobiology Pitt Psychiatry investigators...

Nature Medicine: Phospho-tau Serine-262 and Serine-356 as Biomarkers of Pre-tangle Soluble Tau Assemblies in Alzheimer’s Disease

Thomas Karikari, PhD

Neurofibrillary tangles are a defining neuropathological feature of Alzheimer’s disease. Patients with Alzheimer’s disease with little or no quantifiable insoluble brain tau neurofibrillary tangle pathology demonstrate stronger clinical benefits of therapies than those with advanced neurofibrillary tangles. The formation of neurofibrillary tangles can be prevented by targeting the intermediate soluble tau...

Nature Neuroscience: Dissociable Control of Motivation and Reinforcement by Distinct Ventral Striatal Dopamine Receptors

Dr. Zachary Freyberg

Dopamine transmission is essential for reward processes including motivation and reinforcement. Motivation is the internal process activating and directing behavior, and reinforcement increases the likelihood of a behavior through stimulus–response and action–outcome associations. The nucleus accumbens medial shell within the striatum serves as a key hub for reward-related behaviors, receiving dopaminergic inputs...

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