Publications

Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: A randomized placebo-controlled trial Lenze EJ, Mulsant BH, Blumberger DM, Karp JF, Newcomer JW, Anderson SJ, Dew MA, Butters MA, Stack JA, Begley AE and Reynolds CF The Lancet, 2015; 386(10011):2404-2412. Treatment-resistant major depressive disorder is common and potentially life...

Functional Near-Infrared Spectroscopy Evidence for Development of Prefrontal Engagement in Working Memory in Early Through Middle Childhood Perlman SB, Huppert TJ and Luna B Cerebral Cortex, 2015, 1-10 The neural underpinnings of working memory are hypothesized to develop incrementally across preschool and early school age, coinciding with the rapid maturation of executive function occurring during this period. In...

African Genetic Ancestry is Associated with Sleep Depth in Older African Americans Halder I, Matthews KA, Buysse DJ, Strollo PJ, Causer V, Reis SE and Hall MH SLEEP, 38:1185-1193, 2015 A new study clearly establishes a partial genetic basis underlying racial differences in slow-wave sleep, suggesting that it may be possible to develop sleep-related therapies that target specific genetic variants. Using a panel of 1...

Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges Bylsma LM, Yaroslavsky I, Rottenberg J, Jennings JR, George CJ, Kiss E, Kapornai K, Halas K, Dochnal R, Lefkovics E, Benák I, Baji I, Vetró A and Kovacs M Biological Psychology, 110:167-174, 2015 Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation, and is...

Altered Markers of Cortical ?-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene Kimoto S, Zaki MM, Bazmi HH and Lewis DA JAMA Psychiatry, 72:747-756, 2015 In schizophrenia, working memory deficits appear to reflect abnormalities in the generation of gamma oscillations in the dorsolateral prefrontal cortex. The generation of gamma oscillations requires the phasic excitation of inhibitory...

Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife Ryan JP, Aizenstein HJ, Orchard TJ, Ryan CM, Saxton JA, Fine DF, Nunley KA and Rosano C Psychosomatic Medicine, Published Online, 2015 People diagnosed with type 1 diabetes in later childhood have weaker brain connectivity in midlife compared to those who were diagnosed at earlier ages. Dr. John Ryan, Assistant Professor of...