Publications

Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia Chung DW, Fish KN and Lewis DA American Journal of Psychiatry, 2016 Nov 1;173(11):1131-1139. Deficient excitatory drive to parvalbumin-containing cortical interneurons is proposed as a key neural substrate for altered gamma oscillations and cognitive dysfunction in schizophrenia. However, a pathological entity...

Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward Liu Z, Wang Y, Cai L, Li Y, Chen B, Dong Y, and Huang YH Journal of Neuroscience, Published online, 2016 Sleep profoundly affects the emotional and motivational state. In humans and animals, loss of sleep often results in enhanced motivation for reward, which has direct implications for health risks as well as potential benefits. Dr. Yanhua...

Parsing Heterogeneity in the Brain Connectivity of Depressed and Healthy Adults during Positive Mood Price RB, Lane S, Gates K, Kraynak TE, Horner MS, Thase ME and Siegle GJ Biological Psychiatry, Published online, 2016 Psychiatric diagnoses exhibit significant heterogeneity in symptom presentation. Major depression, for example, has 16,400 possible combinations of symptoms contained within the nine DSM-5 criteria...

Altered expression of ARP2/3 complex signaling pathway genes in prefrontal layer 3 pyramidal cells in schizophrenia Datta D, Arion D, Roman KM, Volk DW and Lewis DA American Journal of Psychiatry, Published online August 2016 Lower dendritic spine density on layer 3 pyramidal cells in the dorsolateral prefrontal cortex (DLPFC) appears to contribute to cognitive dysfunction in schizophrenia, whereas psychosis is...

Neurometabolic disorders: Potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behavior Pan LA, Martin P, Zimmer T, Segreti AM, Kassiff S, McKain BW, Baca CA, Rengasamy M, Hyland K, Walano N, Steinfeld R, Hughes M, Dobrowolski SK, Pasquino M, Diler D, Perel J, Finegold DN, Peters DG, Naviaux RK, Brent DA and Vockley J. American Journal of Psychiatry, 2017, 174(1):42-50...

Time-varying associations between confidence and motivation to abstain from marijuana during treatment among adolescents Chung T and Maisto SA Addictive Behavior, 57:62-68, 2016 An important goal of addictions treatment is to develop a positive association between high levels of confidence and motivation to abstain from substance use. Dr. Tammy Chung examined session-to-session changes in level of confidence and...