Education & Training
- Handen BL, Aman MG, Arnold LE, Hyman SL, Tumuluru MV, Lecavalier L, Corbett-Dick P, Pan X, Hollway JA, Buchan-Page KA, Silverman LB, Brown NV, Rice Jr, RR, Hellings J, Mruzek DW, McAuliffe-Bellin S, Hurt EA, Ryan MM, Levato L, Smith T. Atomoxetine, parent training, and their combination in children with autism spectrum and ADHD. Journal of the American Academy of Child and Adolescent Psychiatry. 2015, 54, 905-915.
- Bearss K, Johnson C, Smith T, Lecavalier L, Swiezy N, Aman M, McAdam DB, Butter E, Stillitano C, Minshawi N, Sukhodolsky D, Mruzek DW, Turner K, Neal T, Hallett V, Mulick JA, Green B, Handen B, Deng Y, Dziura J, Scahill L. Effect of parent training versus parent education on behavioral problems in children with autism spectrum disorder: A randomized clinical trial. JAMA. 2015, 313,1524-1533.
- Anagnostou E, Aman MG, Handen BL, Sanders KB, Shui A, Hollway JA, Brian J, Arnold LE, Capano L, Hellings JA, Butter E, Mankad D, Tumuluru R, Kettel J, Newsom CR, Peleg N, Odrobina D, McAuliffe-Bellin S, Zakroysky P, Marler S, Wagner A, Wong T, Macklin EA, Veenstra-VanderWeele J. A randomized, placebo controlled trial of metformin for the treatment of overweight induced by antipsychotic medication in young people with ASD. JAMA Psychiatry. 2016, 73(9), 928-937.
- Hartley SL, Handen BL, Devenny DA, , Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Bradley T. Christian. Cognitive functioning in relation to the accumulation of brain -amyloid in healthy adults with Down syndrome. Brain, 2014, 137, 2556-2563. PMID:24993958.
- Handen B, Cohen A, Umapathy C, Bulova P, Cannon SA, Cohen WI, Mathis CA, Price JC, Klunk WE. Imaging brain amyloid in non-demented young adults with Down syndrome using PiB-PET. Alzheimer's & Dementia, 2012, 8, 496-501.
$100M+ National Institute on Aging Grant Awarded to Pitt Psychiatry to Investigate Connections Between Down Syndrome and Alzheimer’s Disease
Benjamin Handen, PhD (Professor of Psychiatry), is contact principal investigator (PI) on a newly awarded National Institute of Health (NIH) MPI U19 grant with a budget of $109 million across five years. The project is funded by the National Institute on Aging, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the INCLUDE (INvestigation of Co-occurring conditions across the...
Accumulation of Amyloid Beta in Down Syndrome and Early-onset Alzheimer’s Follows a Different Path Than Late-onset Buildup
The brains of people with early-onset Alzheimer’s and Down syndrome share a distinct pattern of amyloid buildup that is not seen in late-onset Alzheimer’s disease. Future studies on the origin of this unique pattern could reveal important mechanisms of amyloid beta accumulation and possibly targets for early intervention. People with early-onset Alzheimer's disease often develop symptoms of cognitive decline in...
Dr. Benjamin Handen Reports in the Journal of the American Academy of Child & Adolescent Psychiatry that Metformin Decreases Weight Gain in Autistic Children Taking Atypical Antipsychotic Medications
Disruptive behaviors, including aggression, tantrums, and self-injury, are estimated to occur in 20% to 50% of individuals with autism spectrum disorder (ASD). Atypical antipsychotic medications are one of the most common pharmacologic treatments for such behaviors in the ASD population, but significant increases in weight are frequently reported. There also is evidence of an increased risk of diabetes in children...
Study Looks at Alzheimer's Biomarkers in Individuals with Down Syndrome
Dr. Benjamin Handen will lead a new multicenter effort exploring the progression of Alzheimer's-related biomarkers and cognitive/adaptive functioning in adults with Down syndrome with support from a five-year, $12.5 million grant from the National Institute on Aging. Dr. Handen will collaborate with Department of Psychiatry colleagues Drs. William Klunk (co-principal investigator), Howard Aizenstein, Annie Cohen...