Publications

January 11, 2018

Publications

Investigators in the Geriatric Psychiatry Neuroimaging Lab Publish First Study to Explore Cerebral Blood Flow Correlates of Worry Induction in Late Life

Andreescu & Colleagues Translational Psychiatry 2017

Published in Translational Psychiatry Severe worry arises from a complex blend of maladaptive affective and cognitive processes. Contrary to other forms of anxiety, there is no consensus in the field regarding the neural basis of worry. No previous study has looked at cerebral blood flow changes associated specifically with in-scanner induction and reappraisal of worry. In the first study of its kind, Department of...

January 2, 2018

Publications

Enwright et al. Offer New Insights into Cell Type-Specific Molecular Alterations in Schizophrenia

Enwright et al. Molecular Psychiatry 2017

Published in Molecular Psychiatry Department of Psychiatry members John Enwright, PhD; Dominique Arion, PhD; and David A. Lewis, MD, along with colleagues from other departments, have identified cell type-specific molecular alterations in schizophrenia, which could propel strategies for identifying novel therapeutic targets. The researchers investigated the molecular alterations associated with schizophrenia at the...

December 12, 2017

Publications

Hafeman et al. Report on the Usefulness of a Risk Calculator to Predict New-Onset Bipolar Spectrum Disorder in Youth in JAMA Psychiatry

Early identification of individuals at high risk for the onset of bipolar spectrum disorder (BPSD) is key from both a clinical and research perspective. In this study, Dr. Hafeman and colleagues built a risk calculator to predict the five-year onset of BPSD in youth at familial risk. This study tested the degree to which a time-to-event model, including measures of mood and anxiety, general psychosocial functioning...

December 6, 2017

Publications

Hot Publication – Freyberg et al.

Findings by Dr. Zachary Freyberg et al. challenge the existing dogma about how dopamine-releasing neurons communicate, showing that they can change the amount of dopamine released as a function of their overall activity. Malfunctioning of this mechanism could have major implications for many dopamine-related diseases, including schizophrenia, Parkinson’s disease, and addiction. The basics of dopamine signaling...

November 1, 2017

Publications

Hot Publication - Brent & Colleagues

Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial Weersing VR, Brent DA, Rozenman MS, Gonzalez A, Jeffreys M, Dickerson JF, Lynch FL, Porta G and Iyengar S JAMA Psychiatry. Published online Anxiety and depression affect 30% of youth but are markedly undertreated compared with other mental disorders, especially in Hispanic populations. A study by Dr. David...

October 19, 2017

Publications

Hot Publication - MacDonald et al.

Selective Loss of Smaller Spines in Schizophrenia MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA and Sweet RA American Journal of Psychiatry, Published online 2017 Deceased density of dendritic spines in adult schizophrenia subjects has been hypothesized to result from increased pruning of excess synapses in adolescence. In vivo imaging studies have...