Education & Training
Selected Honors & Awards
- I.D. Zike, M.O. Chohan, J.M. Kopelman, E. Krasnow, D. Flicker, K.M. Nautiyal, M. Bubser, C. Kellendonk, C.K. Jones, G.D. Stanwood, K.F. Tanaka, H. Moore, S.E. Ahmari, J. Veenstra-VanderWeele. (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior. PNAS. 114: 5719-5724. PMID: 28507136.
- J. Wood and S.E. Ahmari. A framework for understanding the emerging role of corticolimbic-ventral striatal networks in OCD-associated repetitive behaviors. (2015) Frontiers in Systems Neuroscience. 9:171-83. PMID: 26733823.
- K.M. Nautiyal, K.F. Tanaka, M.M. Barr, L. Tritschler, Y.L. Dantec, D.J. David, A.M. Gardier, C. Blanco, R. Hen, and S.E. Ahmari. (2015) Distinct circuits underlie the effects of 5-HT1B receptors on aggression and impulsivity. Neuron. 86:813-826. PMID: 25892302.
- S.E. Ahmari, T. Eich, D. Cebenoyan, E.E. Smith, and H.B. Simpson. (2014) Assessing neurocognitive function in psychiatric disorders: a roadmap for enhancing consensus. Neurobiology of Learning and Memory. 115:10-20. PMID: 24994503.
- S.E. Ahmari, T. Spellman, N.L. Douglass, M.A. Kheirbek, H.B. Simpson, K. Deisseroth, J.A. Gordon, R. Hen. (2013) Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 340:1234-1239. PMID: 23744948.
The American Journal of Psychiatry: Experimental Manipulation of the Orbitofrontal Cortex Affects Short-Term Markers of Compulsive Behavior
Individuals with compulsive behavior disorders, such as obsessive-compulsive disorder (OCD), experience compulsions in which the ability to engage in flexible goal-directed behavior is impaired in favor of habitual behaviors. Research from both animal and human studies have indicated that alterations within the orbitofrontal cortex are a key factor in the onset of compulsive behaviors. However, questions remain...
Pitt Psychiatry News from the 2019 Annual Meeting of the American College of Neuropsychopharmacology
We are delighted to share Pitt Psychiatry news—as well as a few photographic highlights—from the 58th annual meeting of the American College of Neuropsychopharmacology (ACNP): Mary Phillips, MD, MD (Cantab) (Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders and Professor of Psychiatry and Clinical and Translational Science) has joined the ACNP Council, a tremendous honor that will allow Dr...
Now in Molecular Psychiatry: Department Investigators Uncover Molecular Alterations in Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a disabling illness characterized by obsessions that result in compulsive behavior. Underscoring the need for more effective treatments, existing first-line therapies lead to remission in just 10–15% of patients. However, the development of new therapies requires a better understanding of the molecular abnormalities that are present in OCD. A recent study from Pitt Department...
New Study by Ahmari and Colleagues Links Compulsive Behavior to Abnormal Brain Connectivity in Mice
Compulsive behaviors are some of the most debilitating symptoms of obsessive-compulsive disorder (OCD). Unfortunately, these behaviors are notoriously resistant to current treatments. A recent study by Pitt Department of Psychiatry researchers is the first to identify abnormal connectivity between two brain regions, secondary motor area and striatum, as a possible cause of compulsive behavior, potentially opening...