Faculty

Robert A Sweet, MD

UPMC Endowed Professor in Psychiatric Neuroscience and Professor of Neurology and Clinical and Translational Science

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Website
Assistant
Tracey Capotosto

Education & Training

MD
University of Maryland, School of Medicine
Psychiatry, Albany Medical Center

Professional Affiliations

Fellow, American College of Neuropspychopharmacology
Member, American Association for Geriatric Psychiatry
Member, Society for Biological Psychiatry
Member, Society for Neuroscience

Selected Honors & Awards

APA/AACDP Research Mentorship Award, American Psychiatric Association (APA) and APA Foundation
Geriatric Research Award, American College of Psychiatrists
Distinguished Scientist Award, American Association for Geriatric Psychiatry

Research Interests

Psychosis in Alzheimer's disease; Molecular mechanisms of psychosis; Synaptic alterations in schizophrenia
Selected Research Publications & Products
  1. Krivinko JM, Erickson SL, MacDonald ML, Garver ME, Sweet RAC. Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice. Alzheimers & Dementia: Translational Research & Clinical Interventions. 2022; 8(1): e12324. PMCID: PMC9395154
  2. DeMichele-Sweet MA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Trraga L, Boada M, Alarcn-Martn E, Valero S; NIA-LOAD Family Based Study Consortium, Alzheimers Disease Genetics Consortium (ADGC), Liu Y, Hooli B, Aarsland D, Selbaek G, Bergh S, Rongve A, Saltvedt I, Skjellegrind HK, Engdahl B, Stordal E, Andreassen OA, Djurovic S, Athanasiu L, Seripa D, Borroni B, Albani D, Forloni G, Mecocci P, Serretti A, De Ronchi D, Politis A, Williams J, Mayeux R, Foroud T, Ruiz A, Ballard C, Holmans P, Lopez OL, Kamboh MI, Devlin B, Sweet RAC. Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Mol Psychiatry. 2021 Oct;26(10):5797-5811. PMCID: PMC8660923
  3. Grubisha MJ, Sun X, MacDonald ML, Garver M, Sun Z, Paris KA, Patel DS, DeGiosio RA, Lewis DA, Yates NA, Camacho C, Homanics GE, Ding Y, Sweet RAC. MAP2 is differentially phosphorylated in schizophrenia, altering its function. Mol Psychiatry. 2021 Sep;26(9):5371-5388. PMCID: PMC8325721
  4. MacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA. Synaptic proteome alterations in the primary auditory cortex of individuals with schizophrenia. JAMA Psychiatry. 2019 Oct 23:1-10. PMCID: PMC6813579.
  5. Javitt DC & Sweet RA. Auditory dysfunction in schizophrenia: Integrating clinical and basic features. Nat Rev Neurosci. 2015 Aug 20;16(9):535-50. PMCID: PMC4692466

Clinical Interests

Alzheimer's disease

Education Interests

Research training; Postdoctoral career and research development