Robert A Sweet, MD

UPMC Endowed Professor in Psychiatric Neuroscience and Professor of Psychiatry and Neurology

Areas of Expertise

  • Older Adults
  • Psychosis
  • Basic & Translational Neuroscience
Robert A Sweet, MD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Psychosis in Alzheimer's disease; Molecular mechanisms of psychosis; Synaptic alterations in schizophrenia

Clinical Interests

Alzheimer's disease

Education Interests

Research training; Postdoctoral career and research development

Selected Publications

  1. Krivinko JM, Fan P, Sui Z, Happe C, Hensler C, Gilardi J, Ikonomovic MD, McKinney BC, Newman J, Ding Y, Wang L, Sweet RA, MacDonald ML. Age-related loss of large dendritic spines in the precuneus is statistically mediated by proteins which are predicted targets of existing drugs. Mol Psychiatry. 2025 May;30(5):2059-2067. doi: 10.1038/s41380-024-02817-w. Epub 2024 Nov 13. PMID: 39537705.
  2. Lyu J, MacDonald ML, Ruiz S, Chou S, Gilardi J, Buchwald SC, Grubisha MJ, Sweet RA. Deciphering the alteration of MAP2 interactome caused by a schizophrenia-associated phosphorylation. Neurobiol Dis. 2024 Dec;203:106731. doi: 10.1016/j.nbd.2024.106731. Epub 2024 Nov 10. PMID: 39532265.
  3. Chou S, Fish KN, Lewis DA, Sweet RA. Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: A pilot study. Neurobiol Dis. 2023 Sep;185:106262. doi: 10.1016/j.nbd.2023.106262. Epub 2023 Aug 15. PMID: 37586566; PMC10120624
  4. Krivinko JM, DeChellis-Marks MR, Zeng L, Fan P, Lopez OL, Ding Y, Wang L, Kofler J, MacDonald ML, Sweet RA. Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease. Commun Biol. 2023 Jun 2;6(1):598. doi: 10.1038/s42003-023-04961-5. PMID: 37268664; PMCID: PMC10238472.
  5. DeMichele-Sweet MA, Klei L, Creese B, Harwood JC, Weamer EA, McClain L, Sims R, Hernandez I, Moreno-Grau S, Trraga L, Boada M, Alarcn-Martn E, Valero S; NIA-LOAD Family Based Study Consortium, Alzheimers Disease Genetics Consortium (ADGC), Liu Y, Hooli B, Aarsland D, Selbaek G, Bergh S, Rongve A, Saltvedt I, Skjellegrind HK, Engdahl B, Stordal E, Andreassen OA, Djurovic S, Athanasiu L, Seripa D, Borroni B, Albani D, Forloni G, Mecocci P, Serretti A, De Ronchi D, Politis A, Williams J, Mayeux R, Foroud T, Ruiz A, Ballard C, Holmans P, Lopez OL, Kamboh MI, Devlin B, Sweet RA. Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease. Mol Psychiatry. 2021 Oct;26(10):5797-5811. PMCID: PMC8660923

Education & Credentials

Education & Training

Education
MD, University of Maryland, School of Medicine
Residency
Psychiatry, Albany Medical Center

Professional Affiliations

  • Fellow, American College of Neuropspychopharmacology
  • Member, American Association for Geriatric Psychiatry
  • Member, Society for Biological Psychiatry
  • Member, Society for Neuroscience

Selected Honors & Awards

  • APA/AACDP Research Mentorship Award, American Psychiatric Association (APA) and APA Foundation
  • Geriatric Research Award, American College of Psychiatrists
  • Distinguished Scientist Award, American Association for Geriatric Psychiatry

Related News