Education & Training
Selected Honors & Awards
- MacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA. Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia. JAMA Psychiatry. 2019 Oct 23:1-10. PMID: 31642882.
- MacDonald ML, Alhassa J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA. Selective Loss of Smaller Spines in Schizophrenia. American Journal of Psychiatry, In Press.
- MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA. Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. Biol Psychiatry. 2015;77:959-968.
- MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain Tissue. Mol Cell Proteomics. 2012 Dec;11(12):1670-81.
- MacDonald ML, Eaton M, Dudman T, Konradi K. Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biological Psychiatry. 1;57(9):1041-51, 2005.
Pitt Psychiatry News from the 2019 Annual Meeting of the American College of Neuropsychopharmacology
We are delighted to share Pitt Psychiatry news—as well as a few photographic highlights—from the 58th annual meeting of the American College of Neuropsychopharmacology (ACNP): Mary Phillips, MD, MD (Cantab) (Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders and Professor of Psychiatry and Clinical and Translational Science) has joined the ACNP Council, a tremendous honor that will allow Dr...
Now in JAMA Psychiatry: Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals with Schizophrenia
Individuals with schizophrenia often exhibit impairments in the processing of auditory sensory information and auditory learning. Previous research has implicated the involvement of synaptic protein networks in the pathology of schizophrenia. The number, type and strength of connections between synapses are governed in large part by complex protein networks. “In order for the synapse to function, many different...
The Department of Psychiatry’s 19th Annual Research Day: A Day to Teach, Learn and Be Inspired
The 19th annual Department of Psychiatry Research Day on June 13, 2019 was our biggest yet! For the 505 faculty, postdoctoral students, residents, graduate students and staff who attended, the morning poster session and afternoon program offered a stimulating day of research and career development that was equal parts enlightenment, inspiration, fun and, at times, surprise. The morning session featured 140 posters...
New Findings on Cocaine-Cue Memory Activation and Extinction May Help Reduce the Likelihood of Cue-Motivated Relapse
One of the greatest challenges associated with treating substance use disorders is the heightened attention users give to drug-associated cues, which can produce intense cravings and lead to relapse. One way to reduce the influence of these cues is through extinction learning, in which the cues are presented when the drug is not available, with the goal of reducing the intensity of the association between cocaine...