Colleen A McClung, PhD
Education & Training
Selected Honors & Awards
- Parekh, P.K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., and McClung, C.A. (2017) Altered GluA1 function and accumbal synaptic plasticity in the Clockdelta19 model of bipolar mania. Biological Psychiatry, in press
- Chen, C.Y., Logan, R.W., Tianzhou, M., Lewis, D.A., Tseng, G.C., Sibille, E., and McClung, C.A. (2016) The effects of aging on circadian patterns of gene expression in the human prefrontal cortex. Proc Natl Acad Sci, USA, 113:206-11.
- Sidor, M.M., Spencer, S., Dzirasa, K., Parekh, P.K., Tye, K.M., Warden, M.R., Arey, R.N., Enwright III, J.F., Jacobsen, J.P.R., Kumar, S., Remillard, E.M., Caron, M.G., Deisseroth, K., and McClung, C.A. (2015) Daytime spikes in dopaminergic activity underlie rapid mood-cycling. Molecular Psychiatry, 20:1479-80.
- Ozburn, A.R., Falcon, E., Twaddle, A., Nugent, A.L., Gillman, A.G., Spencer, S.M., Arey, R.N., Mukherjee, S., Lyons-Weiler, J., Self, D.W., and McClung, C.A. (2014) Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biological Psychiatry 77:425-33. *Selected as a priority communication.
- Arey, R., Enwright III, J.F., Spencer, S., Falcon, E., Ozburn, A.R., and McClung, C.A. (2013) An important role for Cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors. Molecular Psychiatry, 19: 342-350.
Biological Psychiatry: Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis
Psychosis, an impairment that manifests as hallucinations and/or delusions, is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Individuals suffering with these illnesses also have major disruptions in sleep and circadian rhythms, which can precipitate or exacerbate psychotic symptoms. A group of investigators including Kyle Ketchesin, PhD (Assistant Professor of Psychiatry), Madeline...
Biological Psychiatry: Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior
Individuals with substance use disorders have disrupted circadian and sleep/wake rhythms, and growing evidence suggests a bidirectional relationship between circadian rhythm disruption and substance abuse. Notably, circadian clocks are integral to the modulation of reward behaviors, and astrocytes—a highly abundant glial cell type that contains a circadian molecular clock—have emerged as key regulators of circadian...
Pitt Psychiatry and Vascular Medicine Institute Collaborate on Wood Next Grant to Study Genetic Factors and Vulnerability to Sleep Disruptions
Colleen McClung, PhD (Professor of Psychiatry and Clinical and Translational Science, and Director, Center for Adolescent Reward, Rhythms and Sleep), and Stephen Chan, MD, PhD, FAHA (Professor of Medicine, and Director, Vascular Medicine Institute), have been awarded $6.2 million to fund two research projects related to the association between genetics and sleep disruptions. Project 1 aims to identify genetic...
Colleen McClung, PhD, Receives Brain & Behavior Research Foundation Colvin Prize for Outstanding Achievement in Mood Disorders Research
We are delighted to congratulate Colleen McClung, PhD (Professor of Psychiatry and Clinical and Translational Science), who has received a 2021 Brain & Behavior Research Foundation (BBRF) Colvin Prize for Outstanding Achievement in Mood Disorders Research. Dr. McClung was honored at the recent International Mental Health Research Virtual Symposium, where she delivered a presentation on the relationship between...