David A Lewis, MD

Distinguished Professor of Psychiatry and Neuroscience, Thomas Detre Professor of Academic Psychiatry, and Chair, Department of Psychiatry

Current Appointments

  • Distinguished Professor of Psychiatry and Neuroscience,
  • Thomas Detre Professor of Academic Psychiatry, Department of Psychiatry
  • Chair, Department of Psychiatry

Areas of Expertise

  • Psychosis
  • Basic & Translational Neuroscience
David A Lewis, MD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Schizophrenia; Cognition; Cortical circuitry

Clinical Interests

Schizophrenia; Psychosis

Education Interests

Research training; Career development

Selected Publications

  1. Gonzalez-Burgos G, Miyamae T, Nishihata Y, Krimer OL, Wade K, Fish KN, Arion D, Cai ZL, Xue M, Stauffer WR, Lewis DA: Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex. J Neurophysiol 133:399-413, 2025.
  2. Arion D, Enwright JF, Gonzalez-Burgos G, Lewis DA: Cell type-specific profiles and developmental trajectories of transcriptomes in primate prefrontal layer 3 pyramidal neurons: Implications for schizophrenia. Am J Psychiatry 181:920-934, 2024.
  3. Schoonover KE, Dienel SJ, Bazmi HH, Enwright JF, Lewis DA: Altered excitatory and inhibitory ionotropic receptor subunit expression in the cortical visuospatial working memory network in schizophrenia. Neuropsychopharmacology 49:1183-1192, 2024.
  4. Fish KN, Sweet RA, MacDonald ML, Lewis DA: Regional specificity of cortical layer 3 dendritic spine deficits spine deficits in schizophrenia. JAMA Psychiatry Published online September 17, 2025. doi:10.1001/jamapsychiatry.2025.2221
  5. Dienel SJ, Wade KL, Fish KN, Lewis DA: Alterations in prefrontal cortical somatostatin neurons in schizophrenia: Evidence for weaker inhibition of pyramidal neuron dendrites. Biol Psychiatry 98:156-166, 2025.
  6. Lewis DA, Dienel SJ, Chung DW: Searching for the final proof of schizophrenia. Schizophr Res 242:78-80, 2022.
  7. Dienel S and Lewis DA: Neural and circuit mechanisms of cognitive dysfunction in schizophrenia: Human studies. In DS Charney, JD Buxbaum, Binder EB, Gordon JA, Picciotto MR, EJ Nestler (eds) Charney & Nestlers Neurobiology of Mental Illness, 6e, Oxford University Press, New York, pp.185-194, 2025.
  8. Volk DW, Jenkins AK, and Lewis DA: Schizophrenia. In RN Rosenberg and JM Pascual (eds) Rosenbergs Molecular and Genetic Basis of Neurological and Psychiatric Disease, 7e, Vol 2, Elsevier, San Diego, pp. 927-936, 2025.
  9. Dienel SJ, Schoonover K, Lewis DA: Cognitive dysfunction and prefrontal cortical circuit alterations in schizophrenia: Developmental trajectories. Biol Psychiatry 92:450-459, 2022.
  10. Chung DW, Geramita MA, Lewis DA: Synaptic variability and cortical gamma oscillation power in schizophrenia. Am J Psychiatry 179:277-287, 2022.
  11. Fertig AM, Tew JD, Douaihy AB, Nash KC, Solai LK, Travis MJ, Zippay LB, Matthews KA, Lewis DA: Developing a clinician educator faculty development program: Lessons learned. Acad Psychiatry 41:417-422, 2017
  12. Gopalan P, Azzam PN, Travis MJ, Schlesinger A, Lewis DA: Longitudinal interdisciplinary neuroscience curriculum. Acad Psychiatry 38:163-167, 2014

Education & Credentials

Education & Training

Education
MD, The Ohio State University, College of Medicine
Residency
Psychiatry, University of Iowa Hospitals and Clinics
Residency
Internal Medicine, University of Iowa Hospitals and Clinics
Postdoctoral
Neuroscience, Scripps Clinic and Research Foundation

Professional Affiliations

  • Elected Member, National Academy of Medicine
  • Fellow, American College of Neuropsychopharmacology
  • Elected Member, Association of American Physicians

Selected Honors & Awards

  • Gold Medal Award, Society of Biological Psychiatry
  • Research in Psychiatry Award, American Psychiatric Association
  • NARSAD Lieber Prize for Schizophrenia Research, Brain & Behavior Research Foundation

Related News