Alexandre Y Dombrovski, MD

Pittsburgh Foundation Endowed Professor in Brain and Mind Research and Professor of Psychiatry and Psychology

Areas of Expertise

  • Mood Disorders
  • AI & Computational Methods
  • Basic & Translational Neuroscience
  • Suicidality & Self-Harm
Alexandre Y Dombrovski, MD
Expertise & Interests Selected Publications Education & Credentials Related News

Expertise & Interests

Research Interests

Decision-making in psychopathology; Reinforcement learning

Clinical Interests

Late-life suicide; Late-life depression

Education Interests

Research mentorship

Selected Publications

  1. Allen, TA, Hallquist, MN, Dombrovski, AY. (2024) The dark side of mentalizing: Learning signals in the default network during social exchanges support cooperation and exploitation. PNAS, 121 (29) e2307221121.
  2. Tsypes A, Hallquist MN, Ianni A, Kaurin A, Wright AGC, Dombrovski AY. (2024) Exploration-exploitation and suicidal behavior in borderline personality and depression. JAMA Psychiatry, 81;(10):1010-1019. doi:10.1001/jamapsychiatry.2024.1796
  3. Hallquist, MN, Hwang, K, Luna, B, Dombrovski, AY. (2024) Reinforcement-based option competition in the dorsal stream during exploration/exploitation of a continuous space. Science Advances, 10 (8). PMID: 38394198 PMCID: PMC10889364
  4. Brown VM, Hallquist MN, Frank MJ & Dombrovski AY. (2022). Humans adaptively resolve the explore-exploit dilemma under cognitive constraints: Evidence from a multi-armed bandit task. Cognition 229, 105233. https://doi.org/10.1016/j.cognition.2022.105233.
  5. Dombrovski AY, Luna B, Hallquist MN. (2020) Differential reinforcement encoding along the hippocampal long axis helps resolve the explore-exploit dilemma. Nature Communications, 26;11(1):5407
  6. Pecia, M, Chen, J, Karp, JF, Dombrovski, AY. (2023) Dynamic feedback between antidepressant placebo expectancies and mood: contributions of dorsal attention and salience networks. JAMA Psychiatry, 80 (4), 389-398.
  7. Allen TA, Hallquist MN, Wright AGC, Dombrovski AY. (2022) Negative affectivity and disinhibition as moderators of an interpersonal pathway to suicidal behavior in borderline personality disorder. Clinical Psychological Science. SAGE Publications Inc; 2022 Jan 3.
  8. Tsypes A, Szanto K, Bridge JA, Brown VM, Keilp JG, Dombrovski AY (2022). Delay discounting in suicidal behavior: Myopic preference or inconsistent valuation? J Abnorm Psychol. 131(1), 3444. doi: 10.1037/abn0000717. PMID: 34843269.
  9. Szucs A, Szanto K, Wright AGC, Dombrovski AY. (2020) Personality of late- and early-onset elderly suicide attempters. Int J Geriatr Psychiatry. Apr;35(4):384-395. doi: 10.1002/gps.5254. Epub 2020 Jan 7. PMID: 31894591; PMCID: PMC7291767.
  10. Dombrovski AY, Hallquist MN, Brown VM, Wilson J, Szanto K. (2019) Value-based choice, contingency learning, and suicidal behavior in mid- and late-life depression. Biol Psychiatry. Mar 15;85(6):506516. PMCID: PMC6380943
  11. Brown VM, Price R, Dombrovski AY (2023). Anxiety as a disorder of uncertainty: Implications for understanding maladaptive anxiety, anxious avoidance, and exposure therapy. CABN, 23 (3), 844-868
  12. Dombrovski AY, Hallquist MN. Search for solutions, learning, simulation, and choice processes in suicidal behavior. WIREs Cognitive Science. 2021; e1561
  13. Kotov R, Cicero DC, Conway CC, DeYoung CG, Dombrovski AY, Eaton NR, First MB, Forbes MK, Hyman SE, Jonas KG, Krueger RF, Latzman RD, Li JJ, Nelson BD, Regier DA, Rodriguez-Seijas C, Ruggero CJ, Simms LJ, Skodol AE, Wright AGC. (2022). Hierarchical Taxonomy of Psychopathology (HiTOP) in psychiatric practice and research. Psychological Medicine. Published online by Cambridge University Press: 02 June 2022.
  14. Hallquist MN, Dombrovski AY. Reinforcement learning approaches in clinical computational neuroscience. In: The Cambridge Handbook of Research Methods in Clinical Psychology edited by Aidan G. C. Wright and Michael N. Hallquist. Cambridge University Press (2020).
  15. Dombrovski AY, Hallquist MN. The decision neuroscience perspective on suicidal behavior: Evidence and hypotheses. Current Opinion in Psychiatry, October 14, 2016.

Education & Credentials

Education & Training

Education
MD, Sechenov Moscow Medical Academy
Residency
Psychiatry, Western Psychiatric Institute and Clinic of UPMC
Fellowship
Geriatric Psychiatry, Western Psychiatric Institute and Clinic of UPMC

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