Publications

Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in MiceLogan RW, Edgar N, Gillman AG, Hoffman D, Zhu X and McClung CA Biological Psychiatry, 78:249-258, 2015 Emerging evidence implicates circadian abnormalities as a component of the pathophysiology of major depressive disorder (MDD). The suprachiasmatic nucleus (SCN) of the hypothalamus...

Molecular Mechanisms and Timing of Cortical Immune Activation in Schizophrenia Volk DW, Chitrapu A, Edelson JR, Roman KM, Moroco AE and Lewis DA American Journal of Psychiatry, 2015 Published Online Immune-related abnormalities are commonly reported in schizophrenia, including higher mRNA levels for the viral restriction factor interferon-induced transmembrane protein (IFITM) in the prefrontal cortex (PFC). However...

Beyond Symptom Counts for Diagnosing Oppositional Defiant Disorder and Conduct Disorder Lindhiem O, Bennett CB, Hipwell AE and Pardini DA Journal of Abnormal Child Psychology, Published Online Conduct Disorder (CD) and Oppositional Defiant Disorder (ODD) are among the most commonly diagnosed childhood behavioral health disorders. Although there is substantial evidence of heterogeneity of symptom presentations, DSM...

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment Cotney J, Muhle RA, Sanders SJ, Liu L, Willsey AJ, Niu W, Liu W, Klei L, Lei J, Yin J, Reilly SK, Tebbenkamp AT, Bichsel C, Pletikos M, Sestan N, Roeder K, State MW, Devlin B and Noonan JP. Nature Communications, 6:6404, 2015 Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD)...

Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and ImpulsivityNautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R and Ahmari SE Neuron, 86:813-826, 2015 New research has found that activity levels at receptors for the neurotransmitter serotonin affect aggression and impulsivity in different ways at different times in the lifespan. These...

A Multisite View of Psychosocial Risks in Patients Presenting for Bariatric Surgery Rofey DL, Zeller MH, Brode C, Reiter-Purtill J, Mikhail C, Washington G, Baughcum AE, Peugh J, Austin H, Jenkins TM, Courcoulas AP and the TeenView Writing Group in cooperation with the Teen-LABS Consortium Obesity, 23:1218-1225, 2015 The psychosocial health of adolescents with severe obesity has only recently been the focus of...