Is Sleep Impaired in a Mouse Model of Sickle Cell Disease?

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Is Sleep Impaired in a Mouse Model of Sickle Cell Disease?

Christopher P. O’Donnell, PhD Executive Vice Chair of Academic Affairs Department of Medicine, Professor of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, Professor of Cell Biology, University of Pittsburgh

The Center for Sleep and Circadian Science is pleased to feature Dr. Christopher O'Donnell as the speaker for the next Grand Rounds.

Christopher O'Donnell, PhD
Christopher P. O’Donnell, PhD

Patients with sickle cell disease (SCD) regularly experience abnormal sleep, characterized by frequent arousals and reduced total sleep time. However, obstructive sleep apnea is a common co-morbidity of SCD, making it unclear whether the disease per se is impacting sleep, or sleep disruption is secondary to the presence of obstructive sleep apnea. Given that mice do not exhibit airway obstruction during sleep, we used a novel mouse model to study the impact of SCD, independent of obstructive sleep apnea, on sleep architecture.

Location: Starzl Biomedical Science Tower, Room 1295

For More Information: Please visit the Sleep and Chronobiology Laboratory website or call 412-246-6451.