For the past 20 years Dr. Bernie Devlin's Lab has had two major foci, the development or refinement of statistical methods for the analysis of genetic data and the implementation of such methods to discover the genetic basis of disease and related phenotypes. The Devlin Lab developed statistical methods appropriate for large-scale genetic studies and applied them and other methods to characterize the genetic basis of autism spectrum disorder and schizophrenia, among others. Recently Dr. Devlin and his team have broadened their focus to include neurobiology, with a goal of helping to understand how genetic variation alters neurodevelopment and thereby generates risk for psychiatric disorders.
Location: Western Psychiatric Institute and Clinic Auditorium
For More Information: Please contact Frances Patrick (patrickfm@upmc.edu).
Learning Objectives: At the conclusion of this lecture, participants will be able to:
Understand how inherited common variation influences risk for autism spectrum disorder.
Describe how and why de novo genetic variation (present in offspring, not in parents) affects risk.
Understand how rare de novo and common inherited variation contribute to risk.