Victor L Villemagne, MD
Education & Training
Selected Honors & Awards
- Burnham SC, Laws SM, Budgeon CA, Dor V, Porter T, Bourgeat P, Buckley RF, Murray K, Ellis KA, Turlach BA, Salvado O, Ames D, Martins RN, Rentz D, Masters CL, Rowe CC, VL Villemagne. (2020) Impact of APOE-e4 carriage on the onset and rates of neocortical A-amyloid deposition. Neurobiol Aging. 95: 46-55.
- VL Villemagne, Velakoulis D, Dor V, Bozinoski S, Masters CL, Rowe CC, Walterfang M. (2019) Imaging of tau deposits in adults with Niemann-Pick type C disease: A case-control study. Eur J Nucl Med Mol Imaging. 46(5):1132-1138.
- Brown BM, Rainey-Smith SR, Dore V, Peiffer JJ, Burnham SC, Laws SM, Taddei K, Ames D, Masters CL, Rowe CC, Martins RN, VL Villemagne. (2018) Self-reported physical activity is associated with tau burden measured by Positron Emission Tomography. J Alzheimers Dis. 63(4):1299-1305.
Microglial and Astrocyte Reactivity Are Key to Determining Alzheimer’s Disease Progression
Tharick Pascoal, MD, PhD (Associate Professor of Psychiatry) is an internationally recognized expert on the imaging and fluid biomarkers of Alzheimer’s disease and related dementias. He recently published two papers examining the multifaceted but interactive nature of Alzheimer’s disease pathology. “Microglia and astrocytes are glial cells that act together and play a major role in the immune response in the human...
New Research from Pitt Psychiatry on Alzheimer’s Disease Biomarkers
Department of Psychiatry investigators focused on Alzheimer’s Research—Victor Villemagne, MD (Professor of Psychiatry); Tharick Pascoal, MD, PhD (Associate Professor of Psychiatry and Neurology); and Thomas Karikari, PhD (Assistant Professor of Psychiatry)—have recently published studies improving our understanding of biomarkers for Alzheimer’s disease. Plasma Glial Fibrillary Acidic Protein Is Associated with 18F...
Genetic Risk for Attention-Deficit/Hyperactivity Disorder Predicts Cognitive Decline and Development Of Alzheimer’s Disease Pathophysiology in Cognitively Unimpaired Older Adults
Attention-deficit/hyperactivity disorder (ADHD) persists in older age and may be a risk factor for cognitive impairment and Alzheimer’s disease. A recent study published in Molecular Psychiatry aimed to determine whether genetic liability for ADHD, as measured by a well-validated ADHD polygenic risk score, is associated with cognitive decline and the development of Alzheimer’s disease pathophysiology in cognitively...
Molecular Psychiatry: Astrocyte Biomarker Signatures of Amyloid-β and Tau Pathologies in Alzheimer’s Disease
In Alzheimer’s disease, reactive astrocytes can play an important role in the pathophysiology of the disease. Amyloid-β and tau tangles—the two main pathological hallmarks of Alzheimer’s disease—are associated with astrocyte reactivity. However, knowledge about amyloid-β- and tau-specific contributions to reactive astrocyte biomarkers in patients with Alzheimer’s disease is limited. To improve our understanding of...