Faculty

Thomas Karikari, PhD

Thomas K Karikari, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara Street
Pittsburgh
 
PA
 
15213
Email

Education & Training

PhD
Neuroscience, University of Warwick
Neuroscience, University of Gothenburg

Professional Affiliations

Committee for Aid in Education in Neurochemistry, International Society for Neurochemistry

Selected Honors & Awards

Best Alzheimer publication Award, Swedish Alzheimer Foundation
Astrup Prize, Nordic Federation for Clinical Chemistry

Research Interests

Pathological changes in the Alzheimer brain; Blood biomarkers for Alzheimers disease diagnosis
Selected Research Publications & Products
  1. Karikari TK*, Pascoal TA*, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schll M, Massarweh G, Soucy J-P, Hglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P & Blennow K (2020). Blood phosphorylated tau 181 as a biomarker for Alzheimers disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurology 19, 422433. https://doi.org/10.1016/S1474-4422(20)30071-5 *Joint first authors
  2. Karikari TK*, Emersic A*, Vrillon A*, Rodriguez JL, Ashton NJ, Kramberg MG, Dumurgier J, Hourregue C, Cucnik S, Brinkmalm G, Rot U, Zetterberg H, Paquet C & Blennow K (2020). Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimers disease diagnosis Alzheimers and Dementia, (2021) May;17(5):755-767. doi: 10.1002/alz.12236. Epub 2020 Nov 30. *Joint first authors
  3. Karikari TK*, Benedet AL*, Ashton NJ*, Lantero Rodriguez J, Snellman A, Surez-Calvet M, Saha-Chaudhuri P, Lussier F, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K & Zetterberg H (2020). Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimers Disease Neuroimaging Initiative. Molecular Psychiatry. https://doi.org/10.1038/s41380-020-00923-z *Joint first authors

Sex Differences in Alzheimer's Disease Blood Biomarkers in a Caribbean Population of African Ancestry: The Tobago Health Study

Thomas Karikari, PhD

Sex Differences in Alzheimer's Disease Blood Biomarkers in a Caribbean Population of African Ancestry: The Tobago Health Study INTRODUCTION: Alzheimer’s disease is increasing in the Caribbean, especially for persons of African ancestry and women. However, studies have mostly utilized surveys without AD biomarkers. METHODS: In the Tobago Health Study (n = 309; 109 women, mean age 70.3 ± 6.6),we assessed sex...

Pitt Psychiatry’s 2024 Research Day, Part I: A Research and Networking Bonanza

Research Day 2024

The 22nd annual Department of Psychiatry Research Day, held on June 13, 2024, was the most highly attended Research Day ever, with 544 faculty members, trainees, and staff gathering at Soldiers & Sailors Memorial Hall & Museum on the University of Pittsburgh campus. Lunchtime Roundtables More than 260 individuals participated in or facilitated one of 19 roundtable discussion groups focused on topics including...

Recently Published in Nature Communications and Alzheimer's & Dementia: Advances in the Diagnosis of Alzheimer's Disease Using Blood Biomarkers

Thomas Karikari, PhD

Recent senior-author studies led by Thomas Karikari, PhD (Assistant Professor of Psychiatry), highlight advances in the diagnosis of Alzheimer's disease using blood biomarkers. Dr. Karikari’s research aims to further understand the molecular and biochemical basis of pathological brain changes that occur in Alzheimer’s patients, and to apply this knowledge to develop new biofluid-based diagnostic tools for clinical...

JAMA Network Open: Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Image of Brain

Neuropsychiatric symptoms including irritability, nighttime disturbances, and agitation are highly prevalent in Alzheimer’s disease and related dementias. Although neuropsychiatric symptoms are clinically well characterized in individuals with Alzheimer’s, scientists have more to learn regarding these symptoms’ neurobiological underpinnings. Investigators including Cristiano Schaffer Aguzzoli, MD (former Pitt...

Alzheimer's & Dementia and Nature Aging: New Alzheimer's Disease Research

Ferrari-Souza et al. Nature Aging 2023 Authors

The Pascoal Lab (PI: Tharick Pascoal, MD, PhD; Associate Professor of Psychiatry and Neurology) and colleagues have published recent research findings in Alzheimer's & Dementia and Nature Aging examining biomarkers and pathophysiological progression of Alzheimer's disease. “These two publications contribute to our understanding of the biomarkers and pathophysiological processes associated with the progression of...