Faculty

Max Joffe, PhD

Max E Joffe, PhD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213

Education & Training

PhD
Pharmacology, Vanderbilt University
Pharmacology, Vanderbilt University

Professional Affiliations

Member, Society for Neuroscience
Member, American Society for Pharmacology and Experimental Therapeutics
Member, Research Society on Alcoholism

Research Interests

Prefrontal cortex; interneurons; Novel pharmacology; Alcohol use disorders & affective disorders
Selected Research Publications & Products
  1. Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons. Neuron. 2022 Jan 13:S0896-6273(21)01044-8. doi: 10.1016/j.neuron.2021.12.027.
  2. Maksymetz J, Byun NE, Luessen DJ, Li B, Barry R, Gore JC, Niswender CM, Lindsley CW, Joffe ME, Conn PJ. mGlu1 potentiation enhances cortical somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits. Cell Reports. 2021 Nov 2;37(5):109950. doi: 10.1016/j.celrep.2021.109950.
  3. Joffe ME, Santiago CI, Oliver KH, Maksymetz J, Harris NA, Engers JL, Lindsley CW, Winder DG, Conn PJ. mGlu2 and mGlu3 negative allosteric modulators divergently potentiate thalamocortical transmission and exert rapid antidepressant-like effects. Neuron. 2020 Jan 8;105(1)46-59. pii: S0896-6273(19)30847-5. doi: 10.1016/j.neuron.2019.09.044. Epub 2019 Nov 14.
  4. Joffe ME, Santiago CI, Engers JL, Lindsley CW, Conn PJ. Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdala-cortical function. Molecular Psychiatry. 2019 Jun; 24(6):916-927. doi:10.1038/s41380-017-0015-z. Epub 2017 Dec 21.
  5. Joffe ME and Grueter BA. Cocaine experience enhances thalamo-accumbens N-methyl-D-aspartate receptor function. Biological Psychiatry. 2016 Nov 1;80(9):671-681.

Education Interests

Research mentoring; Graduate & medical student education