Faculty

Marie Anne Gebara, MD

Marie Anne Gebara, MD

Assistant Professor of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Email

Education & Training

MD
American University of Beirut, Lebanon
Psychiatry, Barnes Jewish Hospital, St. Louis
Geriatric Psychiatry, UPMC Western Psychiatric Hospital
Clinical and Translational Research Training in Geriatric Psychiatry, University of Pittsburgh School of Medicine
Geriatric Psychiatry, VA Pittsburgh Healthcare System

Current Appointments

Medical Director, Ketamine Services, Center for Interventional Psychiatry

Research Interests

Treatment resistant depression; Sleep and mood disorders; Late-life depression
Selected Research Publications & Products
  1. Gebara MA, Kasckow J, Smagula SF, DiNapoli EA, Karp JF, Lenze EJ, Mulsant BH, Reynolds CF 3rd. The role of late life depressive symptoms on the trajectories of insomnia symptoms during antidepressant treatment. J Psychiatr Res.2018;96:162-166. PMCID: PMC5698156
  2. Gebara MA, DiNapoli EA, Kasckow JW, Karp JF, Blumberger DM, Lenze EJ, Mulsant BH, Reynolds CF. Specific depressive symptoms predict remission to aripiprazole augmentation in late-life treatment resistant depression. Int J Geriatr Psychiatry. 2018; 33(2):e330-e335. PMCID: PMC5773368
  3. Gebara MA, Shea ML, Lipsey KL, Teitelbaum SL, Civitelli R, Mller DJ, Reynolds CF 3rd, Mulsant BH, Lenze EJ. Depression, antidepressants, and bone health in older adults: a systematic review. J Am Geriatr Soc. 2014;62(8):1434-41.
  4. Gebara MA, Lipsey KL, Karp JF, Nash MC, Iaboni A, Lenze EJ. Cause or effect? Selective serotonin reuptake inhibitors and falls in older adults: A systematic review. Am J Geriatr Psychiatry. 2015;23(10):1016-28
  5. Gebara MA, Siripong N, DiNapoli EA, Maree RD, Germain A, Reynolds CF, Kasckow JW, Weiss PM, Karp JF.Effect of insomnia treatments on depression: A systematic review and meta-analysis. Depress Anxiety In press, 2018 PMID: 29782076

Clinical Interests

Long-term care; Treatment-resistant depression; Interventional psychiatry: Ketamine, ECT, and TMS
Selected Clinical Publications & Products
  1. Lenze EJ, Mulsant BH, Roose SP, Lavretsky H, Reynolds CF 3rd, Blumberger DM, Brown PJ, Cristancho P, Flint AJ, Gebara MA, Gettinger TR, Lenard E, Miller JP, Nicol GE, Oughli HA, Pham VT, Rollman BL, Yang L, Karp JF. Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression. N Engl J Med. 2023 Mar 23;388(12):1067-1079. doi: 10.1056/NEJMoa2204462. Epub 2023 Mar 3. PMID: 36867173; PMCID: PMC10568698.
  2. Oughli HA, Gebara MA, Ciarleglio A, Lavretsky H, Brown PJ, Flint AJ, Farber NB, Karp JF, Mulsant BH, Reynolds CF 3rd, Roose SP, Yang L, Butters MA, Lenze EJ. Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition. Am J Geriatr Psychiatry. 2023 Mar;31(3):210-221. doi: 10.1016/j.jagp.2022.11.013. Epub 2022 Dec 5. PMID: 36529623; PMCID: PMC10839705.
  3. Gebara MA, DiNapoli EA, Hamm ME, Rodrgiuez KL, Kaskow JW, Lederer LG, Bramoweth AD, Karp JF. Illness Narratives and Preferences for treatment among older veterans living with treatment resistant depression and insomnia. Annals of Clinical Psychiatry. 2020;32(2):81-89. PMID: 32343281
  4. Gebara MA, DiNapoli EA, Lederer LG, Bramoweth AD, Germain A, Kasckow JW, Karp JF. Brief behavioral treatment for insomnia in older adults with late-life treatment resistant depression and insomnia: A pilot study. Sleep and Biological Rhythms. 2019;17(3):287-295. PMCID: PMC6800686

Education Interests

Interventional Psychiatry program development

Psychiatry Residents Present Robust Research at the 7th Annual Psychiatry Research Pathway Symposium

PRP Residents and Mentors

The Psychiatry Research Pathway (PRP) Symposium provides UPMC Western Psychiatric Hospital residents engaged in research the opportunity to present their work to fellow residents, faculty mentors, T32 postdoctoral research program directors, and interested members of our academic community. This year, the PRP Symposium began with a panel discussion focused on interventional psychiatry, moderated by Katherine Lyman...

New Research on Predicting Medication Nonadherence in Older Adults with Difficult-to-Treat Depression in the Incomplete Response in Late-Life Depression Getting to Remission Randomized Controlled Trial

Dr. Sarah Stahl

Over 50% of depressed older adults do not achieve remission with first-line antidepressant treatment, and only half of older adults improve with augmentation or switch to another medication. Multiple factors contribute to poor treatment response including incorrect diagnosis, comorbid physical or psychiatric conditions, and somatic symptoms that overlap with other illnesses. Older adults also experience...

How Pitt Psychiatry Meets the Complex and Evolving Behavioral Health Care Needs of Older Patients

Pitt Psychiatry Meets the Behavioral Health Needs of Older Patients

Skilled and compassionate clinicians and researchers at the Pitt Department of Psychiatry have developed innovative models of care in geriatric psychiatry, as well as training programs that prepare behavioral health care providers to deliver treatment tailored to the specific needs of older adults. Two essential components of effective geriatric psychiatry treatment—access and trust—are key concepts that guide our...