Leslie E Horton, PhD
Assistant Professor of Psychiatry and Psychology
Contact Details
3811 O'Hara St.
Pittsburgh
PA
15213
Email hortonle2@upmc.edu
Website
Education & Training
PhD
Clinical Psychology, University of North Carolina at Greensboro
Clinical Psychology, Western Psychiatric Institute and Clinic of UPMC
Clinical Psychology, University of Pittsburgh
Selected Honors & Awards
Young Investigator Award, International Congress on Schizophrenia Research
Research Interests
Threat dysregulation/social dysfunction & risk; Cognition and affect in adolescence; Ambulatory assessment methodology
Selected Research Publications & Products- Wigman JTW, Ching AE, Chung Y, Eichi HR, Lane E, Langholm C, Vaidyam A, Byun AJS, Haidar A, Hartmann J, Nunez A, Dwyer D, Nasarudin AA, Borders O, Scott I, Tamayo Z, Matneja P, Cho KI, Addington J, Alameda LK, Arango C, Breitborde NJK, Broome MR, Cadenhead KS, Calkins ME, Chen EYH, Choi J, Conus P, Corcoran CM, Cornblatt BA, Diaz-Caneja CM, Ellman LM, Fusar-Poli P, Gaspar PA, Gerber C, Glenthj LB, Horton LE, Hui CLM, Kambeitz J, Kambeitz-Ilankovic L, Keshavan MS, Kim SW, Koutsouleris N, Langbein K, Mamah D, Mathalon DH, Mittal VA, Nordentoft M, Pearlson GD, Perez J, Perkins DO, Powers AR 3rd, Rogers J, Sabb FW, Schiffman J, Shah JL, Silverstein SM, Smesny S, Yassin W, Stone WS, Strauss GP, Thompson JL, Upthegrove R, Verma S, Wang J, Wolf DH, Wolff P; Accelerating Medicines Partnership Schizophrenia (AMP SCZ); Rowland LM, D'Alfonso S, Pasternak O, Bouix S, McGorry PD, Kahn RS, Kane JM, Bearden CE, Woods SW, Shenton ME, Nelson B, Baker JT, Torous J. Digital health technologies in the accelerating medicines Partnership Schizophrenia Program. Schizophrenia (Heidelb). 2025 Jun 3;11(1):83. doi: 10.1038/s41537-025-00599-w. PMID: 40461469; PMCID: PMC12134270.
- Haudrich EA Burns EK, Gupta T, Haas GL & Horton LE. The day-to-day influence of trauma exposure and sleep dysfunction on everyday stress in youth at familial high-risk for psychotic disorders. Schiz. Res. 2024 Dec; 274: 535-544. PubMed PMID: 39586206. DOI: 10.1016/j.schres.2024.10.024.
- Wannan CMJ, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker JT, Bearden CE, Billah T, Bouix S, Broome MR, Buccilli K, Cadenhead KS, Calkins ME, Cannon TD, Cecci G, Chen EYH, Cho KIK, Choi J, Clark SR, Coleman MJ, Conus P, Corcoran CM, Cornblatt BA, Diaz-Caneja CM, Dwyer D, Ebdrup BH, Ellman LM, Fusar-Poli P, Galindo L, Gaspar PA, Gerber C, Glenthj LB, Glynn R, Harms MP, Horton LE, Kahn RS, Kambeitz J, Kambeitz-Ilankovic L, Kane JM, Kapur T, Keshavan MS, Kim SW, Koutsouleris N, Kubicki M, Kwon JS, Langbein K, Lewandowski KE, Light GA, Mamah D, Marcy PJ, Mathalon DH, McGorry PD, Mittal VA, Nordentoft M, Nunez A, Pasternak O, Pearlson GD, Perez J, Perkins DO, Powers AR 3rd, Roalf DR, Sabb FW, Schiffman J, Shah JL, Smesny S, Spark J, Stone WS, Strauss GP, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum IW, Wolf DH, Wolff P, Wood SJ, Yung AR, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrin RE, Castro E, Cetin-Karayumak S, Mallar Chakravarty M, Cho YT, Cotter D, D'Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur RE, Gur RC, Hamilton HK, Hoftman GD, Jacobs GR, Jarcho J, Ji JL, Kohler CG, Lalousis PA, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas SC, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt DN, Rabin R, Rahimi Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari VH, Srivastava A, Thompson A, Turetsky BI, Walsh BC, Whitford T, Wigman JTW, Yao B, Yuen HP, Ahmed U, Byun AJS, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek SH, Bates K, Bathery A, Bayer JMM, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi RI, Chen J, Cheng N, Ching AE, Clifford C, Colton BL, Contreras P, Corral S, Damiani S, Done M, Estrad A, Etuka BA, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui CLM, Suen YN, Wong SMY, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Faria G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods SW, Shenton ME. Accelerating Medicines Partnership Schizophrenia (AMP SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophr Bull. 2024 Apr 30;50(3):496-512. doi: 10.1093/schbul/sbae011. PMID: 38451304; PMCID: PMC11059785.
- Deam MM, Gupta T, Bridgwater MA, Haas GL, Horton LE. Associations between interpersonal trauma and social impairments in adolescents with and without a family history of psychosis. Schizophr Res. 2024 Feb;264:280-281. doi: 10.1016/j.schres.2024.01.002. Epub 2024 Jan 9. PMID: 38198880; PMCID: PMC11867766.
- Bridgwater MA, Horton LE, Haas GL. Premorbid adjustment in childhood predicts later ability to manage emotions in first-episode psychosis. Schizophr Res. 2021; https://doi.org/10.1016/j.schres.2021.11.041.
Clinical Interests
Clinical high-risk for psychosis; Social functioning interventions; Evidence-based practices for early psychosis
Selected Clinical Publications & Products- Horton LE, Mayanil T, & Bylsma LM. Clinical and programmatic considerations for enhancing developmentally-informed care in psychosis-risk programs. Psychiatr. Serv; 2025. PubMed PMID: 39818994. DOI: 10.1176/appi.ps.20240002
- Gupta T, Antezana L, Porter C, Mayanil T, Bylsma L, Maslar M & Horton LE. Skills program for awareness, connectedness, and empowerment: A conceptual framework of a skills group for individuals with a psychosis-risk syndrome. Front. Psychiatry. 2023 March; 14: PubMed PMID: 37025348. DOI: 10.3389/fpsyt.2023.1083368
- Schiffman J, Horton LE, Landa Y & Woods S. Considerations for providing feedback to patients and families regarding clinical high-risk for psychosis status. Schizophr Res. 2022; 244: 55-7. PubMed PMID: 35597133.
- Woods SW, Bearden CE, Sabb F, Stone WS, Torous J, Cornblatt BA, Perkins DO, Cadenhead KS, Addington J, Powers AR, Mathalon DH, Calkins ME, Wolf DH, Corcoran CM, Horton LE, Mittal VA, Schiffman J, Ellman LM, Strauss GP, Mamah D, Choi J, Pearlson GD, Shah JL, Fusar-Poli P, Arango C, Perez J, Koutsouleris N, Wang J, Kwon JS, Walsh BC, McGlashan TH, Hyman SE, Gur RE, Cannon TD, Kane JM, Antecevic, A. Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit. Schizophr Res. 2020; 227: 10-17. PubMed PMID: 37641537.
Education Interests
Research mentorship; Medical student/resident education; Clinical training
