Henry W Chase, PhD
Education & Training
- Chase HW, Grace AA, Fox PT, Phillips ML, Eickhoff SB. Functional differentiation in the human ventromedial frontal lobe: A data-driven parcellation. Hum Brain Mapp. 2020 Aug 15;41(12):3266-3283. doi: 10.1002/hbm.25014. Epub 2020 Apr 21. PMID: 32314470
- Chase HW, Fournier JC, Bertocci MA, Greenberg T, Aslam H, Stiffler R, Lockovich J, Graur S, Bebko G, Forbes EE, Phillips ML. A pathway linking reward circuitry, impulsive sensation-seeking and risky decision-making in young adults: identifying neural markers for new interventions. Translational Psychiatry (2017) 7(4):e1096.
- Chase HW, Phillips ML. Elucidating neural network functional connectivity abnormalities in bipolar disorder: Toward a harmonized methodological approach. Biological Psychiatry Cognitive Neuroscience and Neuroimaging (2016) 1(3):288-298.
- Chase HW, Nusslock R, Almeida JR, Forbes EE, LaBarbara EJ, Phillips ML. Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression. Bipolar Disorders (2013) 15(8):839-854.
- Chase HW, Eickhoff SB, Laird AR, Hogarth L. The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis. Biological Psychiatry (2011) 70(8):785-93.
Biological Psychiatry and Journal of Affective Disorders Research in Mood and/or Bipolar Disorders in Adolescence
New research from Pitt Psychiatry investigators provides insight into the development of anxiety, depression, and/or bipolar in adolescence. A Biological Psychiatry study examines the association between trauma exposure, reward neural circuitry function, and affective and anxiety disorders. In the Journal of Affective Disorders, investigators study whether child maltreatment and cognitive function influence the...
Now in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Assessing Relationships Among Impulsive Sensation Seeking & Reward
Scientists seeking to improve understanding of bipolar disorder have focused on impulsive sensation seeking—a complex trait characterized by impulsivity (acting without advance thought) and sensation seeking (seeking new or extreme experiences). Some research has indicated that high impulsivity may be an early sign or symptom of bipolar disorder. Impulsive sensation seeking is associated with the greater valuation...
Study Is First to Show Impact of Transcranial Direct Current Stimulation on Reward and Affect in Bipolar Disorder
Bipolar disorder is a debilitating mental illness and the fourth leading cause of neurological disability worldwide. There is an urgent need for novel interventions that produce sustained alleviation of symptoms while not introducing challenging, long-term side effects. Previous studies have demonstrated abnormally elevated activity during reward expectancy in the left ventrolateral prefrontal cortex among...
Department of Psychiatry Researchers Study How Trauma-affected Connectivity During Reward Learning Predicts Anxiety & Depression in Young Adults
When children and adolescents experience trauma, they are at risk for depression and anxiety. One way that this can occur is through trauma-induced impairment of the ventral striatum, a key region of the brain associated with reward learning. Impaired reward processing is associated with depression and anxiety in adolescence and adulthood, and young people with depression experience abnormally low ventral striatum...