Faculty

Helmet T Karim, PhD

Assistant Professor of Psychiatry and Bioengineering

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Email
Website
Website

Education & Training

PhD
Bioengineering, University of Pittsburgh, School of Engineering
Geriatric Psychiatry, University of Pittsburgh School of Medicine

Professional Affiliations

Member, Society of Biological Psychiatry

Research Interests

Prediction of treatment response; Risk assessment in Alzheimer's disease; Novel interventions using TMS
Selected Research Publications & Products
  1. Ly M, Gary ZY, Karim HT, Muppidi NR, Mizuno A, Klunk WE, ... & Alzheimer's Disease Neuroimaging Initiative. (2019). Improving brain age prediction models: incorporation of amyloid status in Alzheimer's disease. Neurobiology of Aging.
  2. Karim HT, Wang M, Andreescu C, Tudorascu D, Butters MA, Karp JF, ... & Aizenstein HJ. (2018). Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression. NeuroImage: Clinical, 19, 831-839.
  3. Karim HT, Andreescu C, Tudorascu D, Smagula SF, Butters MA, Karp JF, ... & Aizenstein HJ. (2017). Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters. Molecular psychiatry, 22(3), 450-457.
  4. Karim HT, Tudorascu DL, Butters MA, Walker S, Aizenstein HJ, & Andreescu C. (2017). In the grip of worry: Cerebral blood flow changes during worry induction and reappraisal in late-life generalized anxiety disorder. Translational psychiatry, 7(8), e1204-e1204.
  5. Kay DB, Karim HT, Soehner AM, Hasler BP, Wilckens KA, James JA, ... & Germain A. (2016). Sleep-wake differences in relative regional cerebral metabolic rate for glucose among patients with insomnia compared with good sleepers. Sleep, 39(10), 1779-1794.

Clinical Interests

Novel clinical interventions; Maximizing clinical efficacy

Education Interests

Research mentorship; Graduate student advising; Postdoctoral mentorship

Independent Replication of Advanced Brain Age in Mild Cognitive Impairment and Dementia: Detection of Future Cognitive Dysfunction

Karim et al. Molecular Psychiatry 2022 Article

Models of the aging process are becoming prevalent in multiple fields, and over the last decade, scientists have used brain aging markers to identify important neuroanatomical differences in multiple psychiatric disorders. These markers may provide individualized risk assessments and predictions for age-associated neurodegenerative diseases, and have recently been used to demonstrate the association between greater...

Pitt Psychiatry Awarded $11.5M National Institute of Mental Health Center Grant Focused on Investigating Emotional and Mental Health in Autistic Adults

ACE Center Grant Investigators

The National Institute of Mental Health has awarded the University of Pittsburgh Department of Psychiatry an Autism Center of Excellence (P50) grant to fund “Mental Health in Autistic Adults: An RDoC Approach.” The University of Pittsburgh Autism Center of Excellence (ACE) will be led by Carla Mazefsky, PhD (Professor of Psychiatry, Psychology, and Clinical and Translational Science). The University of Pittsburgh...

New Research on the Intricate Nature of Worry’s Neural Signature

New Research on the Intricate Nature of Worry’s Neural Signature

Severe worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cardiovascular diseases, cognitive impairment, and accelerated brain aging. A group of investigators, including Pitt Psychiatry scientists Andrew Gerlach, PhD (postdoctoral scholar); Helmet Karim, PhD (Assistant Professor of Psychiatry and Bioengineering); Joseph Kazan, MD (postdoctoral scholar); Howard...