David A Lewis, MD

David A Lewis, MD

Distinguished Professor of Psychiatry and Neuroscience, Thomas Detre Professor of Academic Psychiatry, Chair, Department of Psychiatry

Contact Details

3811 O'Hara St.
Amy Noll

Education & Training

The Ohio State University, College of Medicine Medicine
University of Iowa Hospitals and ClinicsPsychiatry
University of Iowa Hospitals and ClinicsInternal Medicine
Scripps Clinic and Research FoundationNeuroscience

Specialty Certifications

Board Certification
American Board of Psychiatry and Neurology
American Board of Internal Medicine

Current Appointments

Distinguished Professor of Psychiatry and Neuroscience,
Thomas Detre Professor of Academic Psychiatry, Department of Psychiatry
Chair, Department of Psychiatry

Professional Affiliations

Elected Member, National Academy of Medicine
Fellow, American College of Neuropsychopharmacology
Elected Member, Association of American Physicians

Selected Honors & Awards

Gold Medal Award, Society of Biological Psychiatry
Research in Psychiatry Award, American Psychiatric Association
NARSAD Lieber Prize for Schizophrenia Research, Brain & Behavior Research Foundation

Research Interests

Schizophrenia; Cognition; Cortical circuitry
Selected Research Publications & Products
  1. Glausier JR, Enwright JF, Lewis DA: Diagnosis- and cell type-specific mitochondrial functional pathway signatures in schizophrenia and bipolar disorder. Am J Psychiatry, in press.
  2. Gonzalez-Burgos G, Miyamae T, Krimer Y, Gulchina Y, Pafundo D, Krimer O, Bazmi H, Arion D, Enwright JF, Fish KN, Lewis DA: Distinct properties of layer 3 pyramidal neurons from prefrontal and parietal areas of the monkey neocortex. J Neurosci 39: 7277-7290, 2019.
  3. Enwright JF, Huo Z, Arion D, Corradi JP, Tseng G, Lewis DA: Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia. Mol Psychiatry 23:1606-1613, 2018.
  4. Datta D, Arion D, Roman KM, Volk DW, Lewis DA: Altered expression of ARP2/3 complex signaling pathway genes in prefrontal layer 3 pyramidal cells in schizophrenia. Am J Psychiatry 174:163-171, 2017
  5. Chung W, Wills ZP, Fish KN, Lewis DA: Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex. Proc Natl Acad Sci USA 114:E629-E637, 2017

Clinical Interests

Schizophrenia; Psychosis
Selected Clinical Publications & Products
  1. Schoonover KE, Dienel SJ, Lewis DA: Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development. Biomarkers in Neuropsychiatry ePub May 18, 2020.
  2. Bechtold J, Hipwell A, Lewis DA, Loeber R, Pardini D: Concurrent and sustained cumulative effects of adolescent marijuana use on subclinical psychotic symptoms. Am J Psychiatry 173:781-789, 2016
  3. Cho RY, Walker CP, Polizzotto NR, Wozny TA, Fissell C, Chen CA, Lewis DA: Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood. Cereb Cortex 25:1509-1518, 2015
  4. Lewis DA: Cortical circuit dysfunction and cognitive deficits in schizophrenia: Implications for preemptive interventions. Eur J Neurosci 35:1871-1878, 2012
  5. Frankle WG, Cho RY, Mason S, Chen C, Himes M, Walker C, Lewis DA, Mathis CA, Narendran R: [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine induced elevations in GABA levels. PLoS One 7: e32443, 2012

Education Interests

Research training; Career development
Selected Education Publications & Products
  1. Fertig AM, Tew JD, Douaihy AB, Nash KC, Solai LK, Travis MJ, Zippay LB, Matthews KA, Lewis DA: Developing a clinician educator faculty development program: Lessons learned. Acad Psychiatry 41:417-422, 2017
  2. Gopalan P, Azzam PN, Travis MJ, Schlesinger A, Lewis DA: Longitudinal interdisciplinary neuroscience curriculum. Acad Psychiatry 38:163-167, 2014