Education & Training
Selected Honors & Awards
- Datta D, Arion D, Roman KM, Volk DW, Lewis DA: Altered expression of ARP2/3 complex signaling pathway genes in prefrontal layer 3 pyramidal cells in schizophrenia. Am J Psychiatry 174:163-171, 2017
- Chung W, Wills ZP, Fish KN, Lewis DA: Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex. Proc Natl Acad Sci USA 114:E629-E637, 2017
- Arion D, Corradi J, Tang S, Datta D, Boothe F, He A, Cacace A, Zaczek R, Albright C, Tseng G, Lewis DA: Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder. Mol Psychiatry 20:1397-1405, 2015
- Kimoto S, Zaki MM, Bazmi HH, Lewis DA: Altered markers of cortical Gamma-aminobutyric acid neuronal activity in schizophrenia: Role of the NARP gene. JAMA Psychiatry 72:747-756, 2015
- Verrico CD, Gu H, Peterson M, Sampson AR, Lewis DA: Repeated Gamma 9-tetrahydrocannabinol exposure in adolescent monkeys: Persistent effects selective for spatial working memory. Am J Psychiatry 171:416-425, 2014
- Bechtold J, Hipwell A, Lewis DA, Loeber R, Pardini D: Concurrent and sustained cumulative effects of adolescent marijuana use on subclinical psychotic symptoms. Am J Psychiatry 173:781-789, 2016
- Cho RY, Walker CP, Polizzotto NR, Wozny TA, Fissell C, Chen CA, Lewis DA: Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood. Cereb Cortex 25:1509-1518, 2015
- Lewis DA: Cortical circuit dysfunction and cognitive deficits in schizophrenia: Implications for preemptive interventions. Eur J Neurosci 35:1871-1878, 2012
- Frankle WG, Cho RY, Mason S, Chen C, Himes M, Walker C, Lewis DA, Mathis CA, Narendran R: [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine induced elevations in GABA levels. PLoS One 7: e32443, 2012
- Fertig AM, Tew JD, Douaihy AB, Nash KC, Solai LK, Travis MJ, Zippay LB, Matthews KA, Lewis DA: Developing a clinician educator faculty development program: Lessons learned. Acad Psychiatry 41:417-422, 2017
- Gopalan P, Azzam PN, Travis MJ, Schlesinger A, Lewis DA: Longitudinal interdisciplinary neuroscience curriculum. Acad Psychiatry 38:163-167, 2014
New Research in the Journal of Psychopharmacology: Cannabis Use and Working Memory Impairments in Adolescents
As cannabis use increases, questions remain about its impact on users’ cognitive function. Studies have shown that among adolescents, the use of cannabis—specifically its primary psychoactive ingredient, Δ-9-tetrahydrocannabinol (THC)—can be associated with susceptibility to cognitive impairment. Previous research has examined the effects of THC on working memory and other cognitive processes in adolescence, but...
Now in The Journal of Neuroscience: Regional Differences among Pyramidal neurons in the Working Memory Cortical Network
Working memory, the ability to maintain a limited amount of information “in mind” to guide everyday thoughts and behaviors, is a core cognitive process. Its function depends on activity in a network of brain areas distributed across the cerebral cortex. Each of these areas display different patterns of activity while information is being maintained. These differences are correlated with, and might depend on...
Now in Molecular Psychiatry: Department Investigators Uncover Molecular Alterations in Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a disabling illness characterized by obsessions that result in compulsive behavior. Underscoring the need for more effective treatments, existing first-line therapies lead to remission in just 10–15% of patients. However, the development of new therapies requires a better understanding of the molecular abnormalities that are present in OCD. A recent study from Pitt Department...
Now in Psychological Medicine: Addressing Challenges to Cognitive Aptitude Assessment in Postmortem Subjects with Schizophrenia
A deep understanding of the neural basis of cognitive impairment in schizophrenia is critical for the development of treatments for this disorder, as cognitive dysfunction can predict clinical outcomes such a relapse frequency and everyday functioning. Achieving this level of understanding is possible by studying post-mortem human brain tissue. However, thus far, scientists have been prevented from doing so due to...