Faculty

David A Lewis, MD

David A Lewis, MD

Distinguished Professor of Psychiatry and Neuroscience, Thomas Detre Professor of Academic Psychiatry, Chair, Department of Psychiatry

Contact Details

3811 O'Hara St.
Pittsburgh
 
PA
 
15213
Website
Assistant
Amy Noll

Education & Training

MD
The Ohio State University, College of Medicine
Psychiatry, University of Iowa Hospitals and Clinics
Internal Medicine, University of Iowa Hospitals and Clinics
Neuroscience, Scripps Clinic and Research Foundation

Specialty Certifications

Board Certification
American Board of Psychiatry and Neurology
American Board of Internal Medicine

Current Appointments

Distinguished Professor of Psychiatry and Neuroscience,
Thomas Detre Professor of Academic Psychiatry, Department of Psychiatry
Chair, Department of Psychiatry

Professional Affiliations

Elected Member, National Academy of Medicine
Fellow, American College of Neuropsychopharmacology
Elected Member, Association of American Physicians

Selected Honors & Awards

Gold Medal Award, Society of Biological Psychiatry
Research in Psychiatry Award, American Psychiatric Association
NARSAD Lieber Prize for Schizophrenia Research, Brain & Behavior Research Foundation

Research Interests

Schizophrenia; Cognition; Cortical circuitry
Selected Research Publications & Products
  1. Dienel SJ, Fish KN, Lewis DA. The nature of prefrontal cortical GABA neuron alterations in schizophrenia: Markedly lower somatostatin and parvalbumin gene expression without missing neurons. Am J Psychiatry. 2023 Jul 1;180(7):495-507.
  2. Dowling KF, Dienel SJ, Barile Z, Bazmi HH, Lewis DA. Localization and diagnostic specificity of glutamic acid decarboxylase transcript alterations in the dorsolateral prefrontal cortex in schizophrenia. Biol Psychiatry. 2023 Aug 15;94(4):322-331.
  3. Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA. Diagnostic specificity and association with cognition of molecular alterations in prefrontal somatostatin neurons in schizophrenia. JAMA Psychiatry. 2023 Aug 30. doi: 10.1001/jamapsychiatry.2023.2972. Online ahead of print. PMID: 37647039
  4. Arion D, Enwright JF, Gonzalez-Burgos G, Lewis DA: Differential gene expression between callosal and ipsilateral projection neurons in the monkey dorsolateral prefrontal and posterior parietal cortices. Cereb Cortex. 2023 Feb 20;33(5):1581-1594.
  5. Gonzalez-Burgos G, Miyamae T, Nishihata Y, Krimer OL, Lewis DA: Strength of excitatory inputs to layer 3 pyramidal neurons during synaptic pruning in the monkey prefrontal cortex: relevance for the pathogenesis of schizophrenia. Biol Psychiatry 94:288-296, 2023.

Clinical Interests

Schizophrenia; Psychosis
Selected Clinical Publications & Products
  1. Schoonover KE, Dienel SJ, Lewis DA: Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development. Biomarkers in Neuropsychiatry ePub May 18, 2020.
  2. Bechtold J, Hipwell A, Lewis DA, Loeber R, Pardini D: Concurrent and sustained cumulative effects of adolescent marijuana use on subclinical psychotic symptoms. Am J Psychiatry 173:781-789, 2016
  3. Cho RY, Walker CP, Polizzotto NR, Wozny TA, Fissell C, Chen CA, Lewis DA: Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood. Cereb Cortex 25:1509-1518, 2015
  4. Lewis DA: Cortical circuit dysfunction and cognitive deficits in schizophrenia: Implications for preemptive interventions. Eur J Neurosci 35:1871-1878, 2012
  5. Frankle WG, Cho RY, Mason S, Chen C, Himes M, Walker C, Lewis DA, Mathis CA, Narendran R: [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine induced elevations in GABA levels. PLoS One 7: e32443, 2012

Education Interests

Research training; Career development
Selected Education Publications & Products
  1. Fertig AM, Tew JD, Douaihy AB, Nash KC, Solai LK, Travis MJ, Zippay LB, Matthews KA, Lewis DA: Developing a clinician educator faculty development program: Lessons learned. Acad Psychiatry 41:417-422, 2017
  2. Gopalan P, Azzam PN, Travis MJ, Schlesinger A, Lewis DA: Longitudinal interdisciplinary neuroscience curriculum. Acad Psychiatry 38:163-167, 2014