Tharick Pascoal, MD, PhD
Associate Professor of Psychiatry and Neurology
Contact Details
3811 O'Hara St.
Pittsburgh
PA
15213
Education & Training
MD
Federal University of Pelotas, Brazil
PhD
Neuroscience, McGill University
Neurology, Pontifical Catholic University of Rio Grande do Sul, Brazil
Neurodegenerative Diseases, Douglas Hospital, McGill University
Neuroscience, McGill University
Professional Affiliations
Member, American Academy of Neurology
Member, Alzheimer's Association's International Society to Advance Alzheimer's Research and Treatment
Research Interests
Alzheimer's disease and related dementias; Biomarkers; Aging
Selected Research Publications & Products- Ferrari-Souza JP, Ferreira PCL, Bellaver B, Tissot C, Wang YT, Leffa DT, Brum WS, Benedet AL, Ashton NJ, De Bastiani MA, Rocha A, Therriault J, Lussier FZ, Chamoun M, Servaes S, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Klunk WE, Tudorascu DL, Cohen AD, Villemagne VL, Gauthier S, Blennow K, Zetterberg H, Souza DO, Karikari TK, Zimmer ER, Rosa-Neto P, Pascoal TA. Astrocyte biomarker signatures of amyloid- and tau pathologies in Alzheimer's disease. Mol Psychiatry. 2022 Aug 10;. doi: 10.1038/s41380-022-01716-2. [Epub ahead of print] PubMed PMID: 35948658.
- Leffa DT, Ferrari-Souza JP, Bellaver B, Tissot C, Ferreira PCL, Brum WS, Caye A, Lord J, Proitsi P, Martins-Silva T, Tovo-Rodrigues L, Tudorascu DL, Villemagne VL, Cohen AD, Lopez OL, Klunk WE, Karikari TK, Rosa-Neto P, Zimmer ER, Molina BSG, Rohde LA, Pascoal TA. Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older adults. Mol Psychiatry. 2022 Dec 8;. doi: 10.1038/s41380-022-01867-2. [Epub ahead of print] PubMed PMID: 36476732.
- Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021 Sep;27(9):1592-1599. doi: 10.1038/s41591-021-01456-w. Epub 2021 Aug 26. PubMed PMID: 34446931.
- Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zrcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak A, Tullo S, Cuello AC, Soucy JP, Massarweh G, Hwang H, Kobayashi E, Hyman BT, Dickerson BC, Guiot MC, Szyf M, Gauthier S, Hooker JM, Rosa-Neto P. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nat Commun. 2022 Jul 19;13(1):4171. doi: 10.1038/s41467-022-30653-5. PubMed PMID: 35853847; PubMed Central PMCID: PMC9296476.
- Tissot C, Servaes S, Lussier FZ, Ferrari-Souza JP, Therriault J, Ferreira PCL, Bezgin G, Bellaver B, Teixeira Leffa D, Mathotaarachchi SS, Chamoun M, Stevenson J, Rahmouni N, Kang MS, Pallen V, Poltronetti NM, Wang YT, Fernandez-Arias J, Benedet AL, Zimmer ER, Soucy JP, Tudorascu DL, Cohen AD, Sharp M, Gauthier S, Massarweh G, Lopresti BJ, Klunk WE, Baker SL, Villemagne VL, Rosa-Neto P, Pascoal TA. The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau-PET in target regions. J Nucl Med. 2022 Nov 17;. doi: 10.2967/jnumed.122.264434. [Epub ahead of print] PubMed PMID: 36396455.
Clinical Interests
Alzheimer's disease and related dementias; Cognitive disorders
