Assembling Tridimensional Models of the Human Brain to Study Development and Disease
We are pleased to welcome Sergiu Pasca, MD from Stanford University on September 13, 2019 for a Special Guest Lecture. Dr. Pasca is Assistant Professor of Psychiatry and Behavioral Sciences at the Stanford Center for Sleep Sciences and Medicine and directs the Stanford Neurosciences Institute Stem Cells Core & Human Brain Organogenesis Program.
A critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation. Dr. Pasca is using pluripotent stem cells derived non-invasively from human individuals to generate in a dish specific regions of the human brain in a functional 3D preparation he and his team have developed. The Pasca lab is using months-to-years long ‘brain-a-dish’ cultures (also known as brain region-specific organoids or spheroids) to understand how neurons find their final position in the brain and how they mature functionally. To investigate how different brain regions talk to each-other in normal and diseased states, the Pasca Lab introduced a new approach for in vitro assembly of neural circuits, also known as assembloids. Dr. Pasca is employing state-of-the-art stem cell biology, genome engineering, imaging and neuroscience approaches to identify the dynamical processes that go awry in neural cells derived from patients with neuropsychiatric disorders, such as autism or schizophrenia, and what should be therapeutically targeted in these conditions.
Date & Time: September 13, 2019, 12:00pm to 1:30pm
Location: UPMC Western Psychiatric Hospital Auditorium
For More Information. Please contact Frances Patrick at email@example.com.
The entirety of this program will be a lecture by the speaker(s). All individuals able to control the content of this educational activity are required to disclose all relevant financial relationships with any proprietary entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients. Registration is not required for this event. This event is free and there will be no refunds. The University of Pittsburgh is an affirmative action, equal opportunity institution.
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