Nadine Melhem, PhD

Associate Professor of Psychiatry

Contact Details

3811 O'Hara St.

Education & Training

University of Pittsburgh, Graduate School of Public Health Psychiatric Epidemiology
American University of Beirut Epidemiology and Biostatistics

Selected Honors & Awards

NARSAD Young Investigator Award, Brain & Behavior Research Foundation
John & Nancy Emerling Fund Young Investigator Award, Pittsburgh Foundation
NARSAD Young Investigator Award, Brain & Behavior Research Foundation
Young Investigator Award, American Foundation for Suicide Prevention

Research Interests

Neurobiology of stress responses; Suicidal behavior; Genetics of brain phenotypes
Selected Research Publications & Products
  1. Melhem NM, Munroe S, Marsland A, Gray K, Brent D, Porta G, Douaihy A, Laudenslager ML, DePietro F, Diler R, Driscoll H, Gopalan P. Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters. Psychoneuroendocrinology 2017 Mar;77:284-294. PubMed PMID: 28135675
  2. Melhem NM, Keilp JG, Porta G, Oquendo MA, Burke A, Stanley B, Cooper TB, Mann JJ, Brent DA. Blunted HPA axis activity in suicide attempters compared to those at high risk for suicidal behavior. Neuropsychopharmacology. 2016 May;41(6):1447-1456. PubMed PMID: 26450815
  3. Melhem NM, Porta G, Shamseddeen W, Walker Payne M, Brent DA. Grief in children and adolescents breaved by sudden parental death. JAMA Psychiatry. 2011 Sep;68(9):911-919. PubMed PMID: 21893658
  4. Hoglinger G*, Melhem NM*, Dickson D*, Sleiman P*, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DC, van Swieten JC, Heutink P, Wszolek Z, Uitti RJ, Vandrovcova J, Hurtig H, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez D, Singleton A, Farrer MJ, Yu CE, Golbe L, Revesz T, Hardy J, Lees A, Devlin B, Hakonarson H, Mller U* & Schellenberg GD*. Identification of common variants influencing risk for the tauopathy Progressive Supranuclear Palsy. Nat Genet. 2011 Jun 19;43(7):699-705. PubMed PMID: 21685912. *These authors contributed equally to this work.
  5. Melhem N, Brent D, Ziegler M, Iyengar S, Kolko D, Oquendo M, Birmaher B, Burke A, Zelazny J, Stanley B, Mann J. Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior. Am J Psychiatry. 2007 Sep;164(9):1364-1370. PubMed PMID: 17728421

Clinical Interests

Selected Clinical Publications & Products
  1. Inventory for Complicated Grief- Revised for Children (ICG-RC). An instrument and screen with established cut-offs developed to measure grief reactions in children. Citation: Melhem NM, Porta G, Walker Payne M, Brent DA. Identifying prolonged grief reactions in children: Dimensional and diagnostic approaches. J Am Acad Child Adolesc Psychiatry 2013 Jun;52(6):599-607. PubMed PMID: 23702449

Education Interests

Mentoring undergraduate and graduate students; Mentoring medical students; Mentoring postdoctoral and visiting fellows