Nadine Melhem, PhD
Education & Training
Selected Honors & Awards
- Melhem NM, Munroe S, Marsland A, Gray K, Brent D, Porta G, Douaihy A, Laudenslager ML, DePietro F, Diler R, Driscoll H, Gopalan P. Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters. Psychoneuroendocrinology 2017 Mar;77:284-294. PubMed PMID: 28135675
- Melhem NM, Keilp JG, Porta G, Oquendo MA, Burke A, Stanley B, Cooper TB, Mann JJ, Brent DA. Blunted HPA axis activity in suicide attempters compared to those at high risk for suicidal behavior. Neuropsychopharmacology. 2016 May;41(6):1447-1456. PubMed PMID: 26450815
- Melhem NM, Porta G, Shamseddeen W, Walker Payne M, Brent DA. Grief in children and adolescents breaved by sudden parental death. JAMA Psychiatry. 2011 Sep;68(9):911-919. PubMed PMID: 21893658
- Hoglinger G*, Melhem NM*, Dickson D*, Sleiman P*, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DC, van Swieten JC, Heutink P, Wszolek Z, Uitti RJ, Vandrovcova J, Hurtig H, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez D, Singleton A, Farrer MJ, Yu CE, Golbe L, Revesz T, Hardy J, Lees A, Devlin B, Hakonarson H, Mller U* & Schellenberg GD*. Identification of common variants influencing risk for the tauopathy Progressive Supranuclear Palsy. Nat Genet. 2011 Jun 19;43(7):699-705. PubMed PMID: 21685912. *These authors contributed equally to this work.
- Melhem N, Brent D, Ziegler M, Iyengar S, Kolko D, Oquendo M, Birmaher B, Burke A, Zelazny J, Stanley B, Mann J. Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior. Am J Psychiatry. 2007 Sep;164(9):1364-1370. PubMed PMID: 17728421
Clinical InterestsSelected Clinical Publications & Products
- Inventory for Complicated Grief- Revised for Children (ICG-RC). An instrument and screen with established cut-offs developed to measure grief reactions in children. Citation: Melhem NM, Porta G, Walker Payne M, Brent DA. Identifying prolonged grief reactions in children: Dimensional and diagnostic approaches. J Am Acad Child Adolesc Psychiatry 2013 Jun;52(6):599-607. PubMed PMID: 23702449
Now In JAMA Psychiatry: Severity and Variability of Depression in Predicting Suicide Attempt in High-Risk Individuals
The ability to predict suicidal behavior in psychiatric patients is one of the most challenging and high-stakes aspects of clinical practice. However, psychiatric diagnoses are of limited value for prediction because the risk for suicidal behavior can vary substantially over the course of a psychiatric illness. Researchers including University of Pittsburgh Department of Psychiatry investigators Nadine Melhem, PhD...
In Longest and Most Detailed Study of Pediatric Grief Following Parental Loss to Date, Department Researchers Find Increased Rates of Depression and Functional Impairment
The death of parent is an incredibly stressful event for a child, and one that can have profound consequences for the child’s future wellbeing. However, little is known about the specific long-term impact of parental loss because these types of studies are challenging to conduct. Pitt Department of Psychiatry researchers recently completed a seven-year prospective examination of pediatric grief following parental...
University of Pittsburgh School of Medicine Promotes Nadine Melhem, PhD to Associate Professor
Nadine Melhem, PhD is an internationally recognized expert on how genetic predisposition and childhood stressors may impact biological processes in the brain to cause early onset depression and suicidal behavior. Her earlier work included adapting an instrument for measuring complicated grief in children that has been used clinically worldwide and collaborating with her colleague, David Brent, MD , included an...
Department of Psychiatry Celebrates Scientific Discovery and Staff and Faculty Contributions at 18th Annual Research Day
The Department of Psychiatry welcomed more than 450 attendees to the 18th Annual Department of Psychiatry Research Day at the University Club on the University of Pittsburgh Oakland campus. The event celebrates the many and diverse research activities of our faculty, trainees, students, and staff. The morning session featured 146 poster presentations representing a wide range of research interests. Faculty experts...