John F Enwright, PhD
Education & Training
- Arion D, Huo Z, Enwright JF, Corradi JP, Tseng G, Lewis DA.Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.Biol Psychiatry. 2017 Apr 4. [Epub ahead of print]PMID:28476208
- Enwright JF, Sonapala S, Foglio A, Berry R, Fish KN, Lewis DA. Integrity of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia. Neuropsychopharmacology. 2016 Aug;41(9):2206-14. PMID: 26868058
- Sidor, MM, Spencer, SM, Dzirasa, K, Parekh, PK, Tye, KM, Warden, MR, Arey, RN, Enwright, JF III, Jacobsen JPR, Kumar, S, Remillard, EM, Caron, MG, Deisseroth, K, and McClung, CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Molecular Psychiatry. 2015 Nov; 20(11):1406-19. PMID: 25560763
- Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T; Lower Gene Expression for KCNS3 Potassium Channel Subunit in Parvalbumin-Containing Neurons in the Prefrontal Cortex in Schizophrenia. Am J Psychiatry. 171(1):62-71, 2014. PMID: 24170294
Enwright et al. Offer New Insights into Cell Type-Specific Molecular Alterations in Schizophrenia
Published in Molecular Psychiatry Department of Psychiatry members John Enwright, PhD; Dominique Arion, PhD; and David A. Lewis, MD, along with colleagues from other departments, have identified cell type-specific molecular alterations in schizophrenia, which could propel strategies for identifying novel therapeutic targets. The researchers investigated the molecular alterations associated with schizophrenia at the...
Hot Publication - Enwright et al.
Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia Enwright JF, Sanapala S, Foglio A, Berry R, Fish KN and Lewis DA Neuropsychopharmacology, Published online, 2016 Alterations in cortical parvalbumin (PV)-containing neurons have frequently been reported in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia subjects. These alter...
McClung and Colleagues
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright III JF, Jacobsen JPR, Kumar S, Remillard EM, Caron MG, Deisseroth K and McClung CA Molecular Psychiatry, Published Online Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction r...
CLOCK Gene and Bipolar Disorder
An Important Role for Cholecystokinin, a CLOCK Target Gene, in the Development and Treatment of Manic-like Behaviors Arey RN, Enwright JF III, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA. Bipolar disorder, characterized by alternating periods of mania and depression, has been associated with disruptions in circadian rhythms, the biological processes that occur on a roughly 24-hour cycle. Eviden...