John F Enwright, PhD
Education & Training
- Arion D, Huo Z, Enwright JF, Corradi JP, Tseng G, Lewis DA.Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders.Biol Psychiatry. 2017 Apr 4. [Epub ahead of print]PMID:28476208
- Enwright JF, Sonapala S, Foglio A, Berry R, Fish KN, Lewis DA. Integrity of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia. Neuropsychopharmacology. 2016 Aug;41(9):2206-14. PMID: 26868058
- Sidor, MM, Spencer, SM, Dzirasa, K, Parekh, PK, Tye, KM, Warden, MR, Arey, RN, Enwright, JF III, Jacobsen JPR, Kumar, S, Remillard, EM, Caron, MG, Deisseroth, K, and McClung, CA. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Molecular Psychiatry. 2015 Nov; 20(11):1406-19. PMID: 25560763
- Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T; Lower Gene Expression for KCNS3 Potassium Channel Subunit in Parvalbumin-Containing Neurons in the Prefrontal Cortex in Schizophrenia. Am J Psychiatry. 171(1):62-71, 2014. PMID: 24170294
Translational Neuroscience Program Faculty Show Circadian Rhythms Regulate Reward through Metabolic Signaling in the Brain
Circadian rhythms are near 24-hour oscillations controlling many aspects of physiology and behavior. The coordination and orchestration of these rhythms maintain homeostasis throughout the body. Evidence from humans suggests disruptions to circadian rhythms and sleep are linked to several psychiatric disorders, including substance use and abuse disorders. Indeed, several human and animal studies have demonstrated...
Enwright et al. Offer New Insights into Cell Type-Specific Molecular Alterations in Schizophrenia
Published in Molecular Psychiatry Department of Psychiatry members John Enwright, PhD; Dominique Arion, PhD; and David A. Lewis, MD, along with colleagues from other departments, have identified cell type-specific molecular alterations in schizophrenia, which could propel strategies for identifying novel therapeutic targets. The researchers investigated the molecular alterations associated with schizophrenia at the...
Hot Publication - Enwright et al.
Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia Enwright JF, Sanapala S, Foglio A, Berry R, Fish KN and Lewis DA Neuropsychopharmacology, 2016 Aug;41(9):2206-2214 Alterations in cortical parvalbumin (PV)-containing neurons have frequently been reported in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia subjects. These...
McClung and Colleagues
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright III JF, Jacobsen JPR, Kumar S, Remillard EM, Caron MG, Deisseroth K and McClung CA Molecular Psychiatry, 2015 Nov;20(11):1406-19 Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their...