David A Brent, MD
Education & Training
Selected Honors & Awards
- Brent DA, Perper JA, Goldstein CE, Kolko DJ, Allan MJ, Allman CJ, Zelenak JP. Risk factors for adolescent suicide. A comparison of adolescent suicide victims with suicidal inpatients. Arch GenPsychiatry. 1988;45:581-588.
- Brent D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, Vitiello B, Ritz L, Iyengar S, Abebe K,Birmaher B, Ryan N, Kennard B, Hughes C, DeBar L, McCracken J, Strober M, Suddath R, Spirito A,Leonard H, Melhem N, Porta G, Onorato M, Zelazny J. Switching to another SSRI or to venlafaxinewith or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: theTORDIA randomized controlled trial. JAMA. 2008;299:901-913.
- Brent DA, Melhem NM, Oquendo M, Burke A, Birmaher B, Stanley B, Biernesser C, Keilp J, Kolko D, Ellis S, Porta G, Zelazny J, Iyengar S, Mann JJ. Familial pathways to early-onsetsuicide attempt: a 5.6 year prospective study. JAMA Psychiatry. Feb 2015;72(2):160-168.
- Brent D, Melhem N, Donohoe MB, Walker M. The incidence and course of depression inbereaved youth 21 months after the loss of a parent to suicide, accident, or sudden natural death. Am J Psychiatry. 2009;166:786-794.
- Brent DA, Brunwasser SM, Hollon SD, Weersing VR, Clarke GN, Dickerson JF, Beardslee WR, Gladstone TR, Porta G, Lynch FL, Iyengar S, Garber J. Effect of a cognitive-behavioralprevention program on depression 6 years after implementation among at-riskadolescents: a randomized clinical trial. JAMA Psych. 2015;72(11):1110-1118.
- Brent DA, Poling K. Cognitive Therapy Manual for Depressed and Suicidal Youth. Pittsburgh: University of Pittsburgh; 1997.
- Poling K, Brent DA, Birmaher B. Understanding and Coping with Bipolar Illness: A Survival Manual for Families. Pittsburgh: WPIC; 1998.
- Kerr MM, Brent DA, McKain B, McCommons PS. Postvention Standards Manual - A Guide for a School's Response in the Aftermath of a Sudden Death. Pittsburgh:University of Pittsburgh; 2010.
- Brent DA, Poling K, Goldstein TR. Treating Depressed and Suicidal Adolescents: A Clinician's Guide New York: Guilford Press; 2011.
K-SADS Becomes One of the Most Widely Used Diagnostic Tools in Research and Clinical Care and Is An Example of How Our Researchers Have Contributed to Improving Assessment of Mental Health Disorders
One of the most significant contributions to the field by Department of Psychiatry investigators is the development and testing of diagnostic tools for research and clinical practice. Assessment of children and adolescents can present unique challenges. For example, mood symptoms are more challenging to evaluate in children than in adults. In 1978 the late Joachim Puig-Antich, MD, a distinguished researcher and...
Hafeman et al. Report on the Usefulness of a Risk Calculator to Predict New-Onset Bipolar Spectrum Disorder in Youth in JAMA Psychiatry
Early identification of individuals at high risk for the onset of bipolar spectrum disorder (BPSD) is key from both a clinical and research perspective. In this study, Dr. Hafeman and colleagues built a risk calculator to predict the five-year onset of BPSD in youth at familial risk. This study tested the degree to which a time-to-event model, including measures of mood and anxiety, general psychosocial functioning...
Hot Publication - Brent & Colleagues
Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Randomized Clinical Trial Weersing VR, Brent DA, Rozenman MS, Gonzalez A, Jeffreys M, Dickerson JF, Lynch FL, Porta G and Iyengar S JAMA Psychiatry. Published online Anxiety and depression affect 30% of youth but are markedly undertreated compared with other mental disorders, especially in Hispanic populations. A study by Dr. David...
Hot Publication - Pan et al.
Neurometabolic disorders: Potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behavior Pan LA, Martin P, Zimmer T, Segreti AM, Kassiff S, McKain BW, Baca CA, Rengasamy M, Hyland K, Walano N, Steinfeld R, Hughes M, Dobrowolski SK, Pasquino M, Diler D, Perel J, Finegold DN, Peters DG, Naviaux RK, Brent DA and Vockley J. American Journal of Psychiatry, 2017, 174(1):42-50...