Faculty

Colleen A McClung, PhD

Professor of Psychiatry and Associate Professor of Clinical and Translational Science

Contact Details

450 Technology Drive
Pittsburgh
 
PA
 
15219
Phone 412-624-5547
Email
Website
The McClung Lab
Assistant
Margaret Carter
cartermp@upmc.edu

Education & Training

PhD
University of Virginia, College and Graduate School of Arts & Sciences Biology
University of Texas Southwestern Medical CenterNeuroscience

Professional Affiliations

Fellow, American College of Neuropsychopharmacology
Member, Society for Neuroscience
Member, Society for Research on Biological Rhythms
Member, Molecular Psychiatry Association

Selected Honors & Awards

NARSAD Independent Investigator Award, Brain & Behavioral Research Foundation
Rising Star Award, International Mental Health Research Organization
Neuroscience of Brain Disorders Award, McKnight Foundation

Research Interests

Circadian rhythms; Mood disorders; Drug addiction
Selected Research Publications & Products
  1. Parekh, P.K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., and McClung, C.A. (2017) Altered GluA1 function and accumbal synaptic plasticity in the Clockdelta19 model of bipolar mania. Biological Psychiatry, in press
  2. Chen, C.Y., Logan, R.W., Tianzhou, M., Lewis, D.A., Tseng, G.C., Sibille, E., and McClung, C.A. (2016) The effects of aging on circadian patterns of gene expression in the human prefrontal cortex. Proc Natl Acad Sci, USA, 113:206-11.
  3. Sidor, M.M., Spencer, S., Dzirasa, K., Parekh, P.K., Tye, K.M., Warden, M.R., Arey, R.N., Enwright III, J.F., Jacobsen, J.P.R., Kumar, S., Remillard, E.M., Caron, M.G., Deisseroth, K., and McClung, C.A. (2015) Daytime spikes in dopaminergic activity underlie rapid mood-cycling. Molecular Psychiatry, 20:1479-80.
  4. Ozburn, A.R., Falcon, E., Twaddle, A., Nugent, A.L., Gillman, A.G., Spencer, S.M., Arey, R.N., Mukherjee, S., Lyons-Weiler, J., Self, D.W., and McClung, C.A. (2014) Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biological Psychiatry 77:425-33. *Selected as a priority communication.
  5. Arey, R., Enwright III, J.F., Spencer, S., Falcon, E., Ozburn, A.R., and McClung, C.A. (2013) An important role for Cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors. Molecular Psychiatry, 19: 342-350.

Clinical Interests

Psychiatric disorders

Education Interests

Training graduate students; Training undergraduate students

Colleen McClung, PhD Appointed Professor by Pitt School of Medicine

Dr. Colleen McClung

Colleen McClung, PhD is a pioneer in the study of how manipulations of limbic circuitry and circadian genes within this circuitry can lead to the development and treatment of psychiatric diseases. She combines molecular, cellular, physiological, and behavioral studies, incorporating new technologies, and these cutting-edge research activities have earned her a superb reputation in her field. Dr. McClung has...

Drs. Colleen A. McClung and Yanhua Huang Find That Nucleus Accumbens Excitatory Signaling Is Integral to Effects of Clock Gene Disruption on Manic-like Behaviors

McClung & Colleagues Biological Psychiatry 2017

Disruptions in circadian rhythms are associated with an increased risk for bipolar disorder, and the circadian protein CLOCK is involved in regulating monoaminergic systems and mood-related behavior. Colleen A. McClung, PhD , Professor of Psychiatry and Yanhua Huang, PhD , Assistant Professor of Psychiatry set out to clarify the molecular and synaptic mechanisms underlying this relationship. Working in...

Drs. Peter Franzen and Colleen McClung Receive NARSAD Independent Investigator Awards

The Department of Psychiatry is pleased to announce that two members of our faculty have been named the latest recipients of NARSAD Independent Investigator Awards by the Brain and Behavior Research Foundation. These two-year grants are awarded to researchers at the associate professor level and are designed to support a broad range of brain research projects. Colleen McClung, PhD Molecular Rhythms and Psychiatric...