Identification and Validation of Protein Phosphorylations Regulating Synapse Loss in Schizophrenia


Identification and Validation of Protein Phosphorylations Regulating Synapse Loss in Schizophrenia

Matthew MacDonald, PhD Assistant Professor of Psychiatry

On July 10, 2020 the University of Pittsburgh Senior Vice Chancellor Seminar Series will feature the work of our own Matthew MacDonald, PhD, Assistant Professor of Psychiatry.

Dr. MacDonald earned a Bachelor’s degree in Biology from Ogelthorpe University in Atlanta, GA, and subsequently gained substantial experience as a Research Technician in the laboratory of Dr. Christine Konradi at McLean Hospital in Boston. After earning a PhD in Pharmacology in 2012, Dr. MacDonald accepted a postdoctoral fellowship in the laboratory of Dr. Robert Sweet in the Pitt Department of Psychiatry’s Translational Neuroscience Program. As a postdoc fellow, Dr. MacDonald utilized multilabeling fluorescence confocal microscopy in parallel with the fractionation – mass spectrometry method that he developed as a graduate student to investigate the role of synaptic pathologies in schizophrenia and other human neuropsychiatric diseases. He was appointed as an Assistant Professor of Psychiatry by the University of Pittsburgh School of Medicine in 2016 where he is using state-of-the-art techniques to map dysfunctions in synaptic protein networks to cortical circuits in schizophrenia. Dr. MacDonald has published numerous peer-reviewed articles on his work in leading scientific journals including the Archives of General Psychiatry and Biological Psychiatry, and presented his findings at conferences and scientific meetings across the United States including the Society for Biological Psychiatry, the International Conference on Schizophrenia Research, and the American College of Neurospsychopharmacology.  

Date & Time. 12:00pm – 1:00pm

Location. Room S100A, Thomas E. Starzl Biomedical Tower

For More Information. Details will be posted on the Senior Vice Chancellor's Seminar Series website as they become available.